Description

(6E)-3β-(Trimethylsiloxy)-9,10-Secocholesta-5(10),6,8-Triene is a high-purity, synthetic steroid derivative and a key advanced intermediate in pharmaceutical research and development. This compound is valued for its specific structural configuration, which makes it a crucial building block in the synthesis of complex steroid-based active pharmaceutical ingredients (APIs). It is primarily utilized by research institutions and pharmaceutical manufacturers focused on developing novel therapeutic agents, particularly in areas such as endocrinology and metabolic disease treatment.

Application

• Pharmaceutical Intermediate: A critical precursor in the multi-step synthesis of complex steroid hormones and related therapeutic compounds.
• Research & Development: Used in academic and industrial laboratories for investigating steroid metabolism and developing new synthetic pathways.
• Reference Standard: Serves as a high-purity analytical standard for quality control and method development in pharmaceutical analysis.
• Process Chemistry: Employed in scale-up and optimization studies for the commercial production of steroid-based APIs.
• Biochemical Probes: Utilized in studies to understand steroid receptor interactions and biological activity mechanisms.

Basic Information

Product Name	(6E)-3β-(Trimethylsiloxy)-9,10-Secocholesta-5(10),6,8-Triene
CAS No.	27281-76-1
Molecular Formula	C30H50OSi
Molecular Weight	454.8 g/mol
Synonyms	3β-(Trimethylsilyloxy)-9,10-secocholesta-5(10),6,8-triene; 9,10-Secocholesta-5(10),6,8-trien-3-ol, 3-(trimethylsilyl) ether; (6E)-3β-Trimethylsiloxy-9,10-secocholesta-5(10),6,8-triene; Vitamin D3 TMS Ether (precursor related); TMS Ether of a 9,10-Secosterol; Steroid TMS Derivative
EINECS	Contact for details

Quality Control

Our (6E)-3β-(Trimethylsiloxy)-9,10-Secocholesta-5(10),6,8-Triene is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, GC, and NMR, to ensure high chemical purity and structural identity. Certificates of Analysis (COA) with detailed chromatographic data are provided to support your R&D and quality assurance requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider using desiccants or an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 97.0%
Related Substances (HPLC)	Total impurities ≤ 3.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.