Description

2-Hydroxy-7,8-Dihydro-5H-Pyrano[4,3-B]Pyridine-3-Carbonitrile is a specialized heterocyclic organic compound featuring a fused pyranopyridine core structure, serving as a critical synthetic intermediate and building block. Its unique molecular architecture, incorporating both nitrile and hydroxyl functional groups, makes it a versatile precursor for the development of novel pharmacologically active molecules. This high-purity chemical is essential for research and development chemists in the pharmaceutical, agrochemical, and fine chemical industries seeking to create new compounds with targeted biological activity.

Application

This advanced chemical intermediate is primarily utilized in sophisticated organic synthesis and research applications. Key uses include:

• Pharmaceutical Research & Development: A key building block for the synthesis of novel drug candidates, particularly in medicinal chemistry programs targeting central nervous system (CNS) disorders, inflammation, and metabolic diseases.
• Agrochemical Innovation: Serves as a precursor in the development of new-generation herbicides, fungicides, and insecticides, leveraging its heterocyclic scaffold.
• Fine Chemical Synthesis: Used in the multi-step synthesis of complex organic molecules, dyes, and functional materials where its fused ring system is required.
• Academic & Contract Research: Employed in university and CRO laboratories for methodological studies, heterocyclic chemistry exploration, and the creation of proprietary chemical libraries.
• Chemical Biology Probes: Acts as a scaffold for developing molecular probes to study enzyme function and biological pathways.

Basic Information

Product Name	2-Hydroxy-7,8-Dihydro-5H-Pyrano[4,3-B]Pyridine-3-Carbonitrile
CAS No.	27152-09-6
Molecular Formula	C9H8N2O2
Molecular Weight	176.17 g/mol
Synonyms	2-Hydroxy-5H-pyrano[4,3-b]pyridine-3-carbonitrile; 5H-Pyrano[4,3-b]pyridine-3-carbonitrile, 2-hydroxy-7,8-dihydro-; 27152-09-6; 2-Hydroxy-7,8-dihydro-5H-pyrano[4,3-b]pyridine-3-carbonitrile; 3-Cyano-2-hydroxy-7,8-dihydro-5H-pyrano[4,3-b]pyridine; Pyrano[4,3-b]pyridine-3-carbonitrile, 2-hydroxy-7,8-dihydro-5H-
EINECS	Contact for details

Quality Control

Our 2-Hydroxy-7,8-Dihydro-5H-Pyrano[4,3-B]Pyridine-3-Carbonitrile is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing to ensure identity, purity, and consistency, meeting the high standards required for research and process development. Certificates of Analysis (COA) detailing specifications such as assay (HPLC), identity (IR, NMR), and impurity profiles are provided with each shipment to guarantee traceability and support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after each use to prevent degradation from atmospheric moisture. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Related Substances (HPLC)	Any individual impurity ≤ 0.5%; Total impurities ≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.