Description

4',4''',5,5'',7,7''-Hexahydroxy-3,3''-Biflavone is a high-purity biflavonoid compound, a dimeric structure formed from two flavone units. This compound is valued for its significant biological activity and serves as a key reference standard and research chemical. It is primarily sought by research institutions and manufacturers in the pharmaceutical, nutraceutical, and life science sectors. Our supply ensures consistent quality and reliable availability for critical development and production needs.

Application

• Pharmaceutical Research & Development: Used as a reference standard and active pharmaceutical ingredient (API) intermediate in drug discovery, particularly for studying antioxidant, anti-inflammatory, and neuroprotective mechanisms.
• Nutraceutical & Dietary Supplement Formulation: Incorporated as a bioactive component in advanced supplements targeting oxidative stress and cellular health due to its potent flavonoid properties.
• Biochemical & Life Science Research: Serves as a critical tool compound in enzymatic studies, cell-based assays, and for investigating structure-activity relationships (SAR) of biflavonoids.
• Cosmeceutical Applications: Evaluated for use in premium skincare formulations for its potential anti-aging and protective benefits against environmental stressors.
• Analytical & Quality Control: Employed as a certified reference material (CRM) for the HPLC/LC-MS quantification of biflavonoids in complex botanical extracts and finished products.

Basic Information

Product Name	4',4''',5,5'',7,7''-Hexahydroxy-3,3''-Biflavone
CAS No.	27090-20-6
Molecular Formula	C₃₀H₁₈O₁₂
Molecular Weight	570.46 g/mol
Synonyms	3,3''-Biflavone, 4',4''',5,5'',7,7''-hexahydroxy-; Amentoflavone 4',4''',5,5'',7,7''-Hexahydroxy Derivative; 4',4''',5,5'',7,7''-Hexahydroxy-3,3''-diflavone; Hexahydroxybiflavone; 3,3''-Biapigenin; NSC 407303; Biflavonoid C30H18O12
EINECS	Contact for details

Quality Control

Every batch of 4',4''',5,5'',7,7''-Hexahydroxy-3,3''-Biflavone undergoes rigorous analytical testing to ensure identity, purity, and consistency. Our quality system is designed to meet the stringent requirements of research and cGMP-grade manufacturing. Comprehensive Certificates of Analysis (COA) detailing purity (by HPLC), identity confirmation (by IR, MS), and impurity profiles are provided with each shipment to support your regulatory and quality assurance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is easily oxidized (store under inert atmosphere) and light-sensitive (store away from light). For long-term storage, consider storing under an inert gas such as argon or nitrogen in a sealed container.

Specification

Item	Specification
Appearance	Yellow to brownish-yellow powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 95.0%
Loss on Drying	≤ 2.0%
Residue on Ignition	≤ 0.5%
Heavy Metals (as Pb)	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.