Description

3-Trifluoromethylbenzamidine is a high-value aromatic amidine derivative, distinguished by the presence of a trifluoromethyl group which imparts unique electronic and steric properties. This compound serves as a critical pharmaceutical intermediate and versatile building block in advanced organic synthesis. It is primarily utilized by research institutions and manufacturers in the pharmaceutical, agrochemical, and specialty chemical industries for developing novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of protease inhibitors, kinase inhibitors, and other small-molecule drug candidates.
• Agrochemical Synthesis: Building block for creating novel herbicides, fungicides, and insecticides with enhanced efficacy and environmental profiles.
• Ligand and Catalyst Development: Used in the preparation of specialized ligands for metal-catalyzed cross-coupling reactions and other catalytic processes.
• Material Science Research: Intermediate for synthesizing functional polymers, liquid crystals, and organic electronic materials.
• Chemical Biology Probes: Serves as a core structure for developing enzyme inhibitors and molecular probes used in biochemical research.
• Custom Synthesis and Contract Manufacturing: Supplied to CDMOs for the production of bespoke compounds and development-scale batches.

Basic Information

Product Name	3-Trifluoromethylbenzamidine
CAS No.	26130-45-0
Molecular Formula	C8H7F3N2
Molecular Weight	188.15 g/mol
Synonyms	3-(Trifluoromethyl)benzamidine; m-Trifluoromethylbenzamidine; Benzenecarboximidamide, 3-(trifluoromethyl)-; α,α,α-Trifluoro-m-toluamidine; 3-Trifluoromethylbenzenecarboximidamide; 3-Carbamimidoylbenzotrifluoride; 3-Amidinobenzotrifluoride
EINECS	Contact for details

Quality Control

Our 3-Trifluoromethylbenzamidine is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC, NMR, and mass spectrometry, to ensure high purity and batch-to-batch consistency. A detailed Certificate of Analysis (COA) is provided with each shipment, confirming compliance with agreed specifications. We support cGMP and ISO standards for pharmaceutical and industrial applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere (e.g., nitrogen or argon) in its original packaging to prevent degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.