Description

4-Bromo-Tetrahydropyran is a versatile brominated heterocyclic building block, essential for advanced organic synthesis. Its reactive bromine atom and protected oxygen functionality make it a critical intermediate for constructing complex molecular architectures. This compound is primarily needed by research institutions and manufacturers in the pharmaceutical, agrochemical, and specialty chemical industries for developing active ingredients and novel materials.

Application

4-Bromo-Tetrahydropyran serves as a key synthetic intermediate in various high-value chemical processes. Its primary applications include:

• Pharmaceutical Intermediate: Used in the synthesis of active pharmaceutical ingredients (APIs), particularly those requiring tetrahydropyran or protected alcohol moieties.
• Agrochemical Synthesis: Acts as a building block for creating herbicides, fungicides, and other crop protection agents.
• Ligand and Catalyst Development: Employed in the research and production of specialized ligands for asymmetric catalysis and metal complexes.
• Polymer Chemistry: Utilized as a monomer or modifying agent in the production of specialty polymers and resins.
• Organic Synthesis: Functions as a pivotal reagent in cross-coupling reactions (e.g., Suzuki, Negishi) and nucleophilic substitution reactions to introduce the tetrahydropyranyl group.
• Flavor and Fragrance Industry: Serves as a precursor for certain aroma chemicals and flavoring agents.

Basic Information

Product Name	4-Bromo-Tetrahydropyran
CAS No.	25637-16-5
Molecular Formula	C5H9BrO
Molecular Weight	165.03 g/mol
Synonyms	4-Bromotetrahydropyran; Tetrahydropyran-4-yl bromide; 4-Bromooxane; 4-Bromotetrahydro-2H-pyran; 4-Bromo-2H-tetrahydropyran; 4-Bromo-2H-pyran, tetrahydro-; Oxane, 4-bromo-
EINECS	Contact for details

Quality Control

Our 4-Bromo-Tetrahydropyran is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chromatography (GC/HPLC) and spectroscopy (NMR, IR), to ensure high purity and consistency. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are provided with every shipment and are available upon request to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Keep away from strong bases and reducing agents. For long-term storage, consider keeping the container under an inert atmosphere to maintain product integrity.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Refractive Index	1.480 - 1.490
Density	1.45 - 1.55 g/cm³

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.