Description

Trimethylsilyl Trichloroacetate is a versatile organosilicon reagent primarily used as a powerful silylating agent and a key intermediate in organic synthesis. Its value lies in its ability to introduce the trimethylsilyl (TMS) protecting group to reactive functional groups like alcohols and carboxylic acids, facilitating complex multi-step synthetic routes. This compound is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and advanced materials sectors who require high-purity intermediates for developing active ingredients and specialty chemicals.

Application

• Pharmaceutical Intermediate: A critical building block in the synthesis of complex drug molecules, particularly for protecting hydroxyl groups during peptide and nucleoside synthesis.
• Agrochemical Synthesis: Used in the production of advanced pesticides and herbicides where specific silylation steps are required for selectivity and yield.
• Polymer & Material Science: Serves as a monomer or modifying agent in the creation of specialized silicone-based polymers and surface coatings.
• Analytical Chemistry: Employed as a derivatization agent in Gas Chromatography (GC) and Mass Spectrometry (MS) to volatilize and analyze polar compounds.
• Organic Synthesis Reagent: Functions as a versatile reagent for acylating and silylating reactions in academic and industrial R&D laboratories.
• Fine Chemical Production: Acts as a key intermediate in the manufacture of flavors, fragrances, and other high-value specialty chemicals.

Basic Information

Product Name	Trimethylsilyl Trichloroacetate
CAS No.	25436-07-1
Molecular Formula	C5H9Cl3O2Si
Molecular Weight	235.57 g/mol
Synonyms	Trichloroacetic Acid Trimethylsilyl Ester; Trimethylsilyl Trichloroethanoate; (Trichloroacetoxy)trimethylsilane; TMS-Trichloroacetate; Silane, (trichloroacetoxy)trimethyl-; Trimethylsilyl Ester of Trichloroacetic Acid; Acetic Acid, Trichloro-, Trimethylsilyl Ester
EINECS	Contact for details

Quality Control

Our Trimethylsilyl Trichloroacetate is produced under stringent quality management systems to ensure batch-to-batch consistency and high purity. Each lot undergoes rigorous analytical testing, including assay by GC or HPLC and impurity profiling, to meet the exacting standards required for synthetic applications. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and specific test results is provided with every shipment and is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); containers must be kept tightly sealed and under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (GC)	≥ 98.0%
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.