Description

Methanesulfonic Acid, Trifluoro-, Cyclopropyl Ester is a specialized fluorinated organic building block of significant interest in advanced chemical synthesis. This compound matters for its unique trifluoromethanesulfonate (triflate) ester group, which serves as an excellent leaving group, enabling critical carbon-carbon and carbon-heteroatom bond-forming reactions. It is primarily needed by research and development chemists and process engineers in the pharmaceutical and agrochemical industries for constructing complex molecular architectures, including active pharmaceutical ingredients (APIs) and novel crop protection agents.

Application

• Pharmaceutical Intermediate: A key reagent in the synthesis of complex drug molecules, particularly those requiring the introduction of cyclopropyl or fluorinated moieties.
• Agrochemical Synthesis: Used in the development of advanced pesticides and herbicides where the cyclopropyl triflate group facilitates selective coupling reactions.
• Material Science Research: Employed in the creation of novel fluorinated polymers and specialty materials with tailored properties.
• Cross-Coupling Reactions: Acts as a superior electrophile in palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Negishi, Stille) for constructing biaryl and other complex structures.
• Nucleophilic Substitution: Serves as a substrate for nucleophilic attack by various anions, enabling functional group interconversions.
• Chemical Process Development: Utilized in route scouting and optimization for the scalable production of high-value fine chemicals.

Basic Information

Product Name	Methanesulfonic Acid, Trifluoro-, Cyclopropyl Ester
CAS No.	25354-42-1
Molecular Formula	C5H5F3O3S
Molecular Weight	202.15 g/mol
Synonyms	Cyclopropyl trifluoromethanesulfonate; Cyclopropyl triflate; Trifluoromethanesulfonic acid cyclopropyl ester; Cyclopropanol, trifluoromethanesulfonate; 1-Cyclopropyl triflate; (Trifluoromethylsulfonyl)oxycyclopropane; CP-Triflate
EINECS	Contact for details

Quality Control

Our Methanesulfonic Acid, Trifluoro-, Cyclopropyl Ester is produced under strict quality management protocols to ensure batch-to-batch consistency and high purity for sensitive synthetic applications. Each lot undergoes rigorous analytical testing, including chromatography (GC/HPLC) and spectroscopy (NMR, IR), to verify identity, potency, and impurity profiles. Certificates of Analysis (COA) detailing all specifications and test results are available upon request, supporting your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area. Due to its hygroscopic (moisture-sensitive) nature, the container should be kept sealed under an inert atmosphere (e.g., nitrogen or argon) when not in use to prevent hydrolysis. Recommended long-term storage temperature is 2-8°C.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.