Description

2,3-Dehydrosilybin A is a specialized flavonolignan derivative, a key intermediate and reference standard in the study of silymarin complex chemistry. This compound matters for its role in advanced pharmaceutical research, particularly in the development and quality control of hepatoprotective and antioxidant formulations derived from milk thistle (Silybum marianum). It is primarily needed by manufacturers and R&D laboratories in the nutraceutical, pharmaceutical, and fine chemical sectors who require high-purity bioactive compounds for analytical and developmental purposes.

Application

• Pharmaceutical Reference Standard: Used as a certified reference material (CRM) for the identification, assay, and impurity profiling of silymarin-based drug products and extracts.
• Nutraceutical Ingredient R&D: Serves as a key intermediate in research for developing standardized, high-potency milk thistle supplements with defined flavonolignan profiles.
• Bioactivity Studies: Employed in pharmacological research to investigate the specific antioxidant, anti-inflammatory, and hepatoprotective mechanisms of individual silymarin components.
• Analytical Chemistry: Essential for method development and validation in HPLC, LC-MS, and other chromatographic techniques used to analyze complex botanical extracts.
• Fine Chemical Synthesis: Acts as a building block or precursor in the semi-synthesis of novel flavonolignan derivatives with potential therapeutic applications.
• Quality Control Laboratories: Critical for in-house QC to ensure the identity, purity, and consistency of raw silymarin materials and finished products.

Basic Information

Product Name	2,3-Dehydrosilybin A
CAS No.	25166-14-7
Molecular Formula	C25H22O10
Molecular Weight	482.44 g/mol
Synonyms	2,3-Dehydrosilybin A; Dehydrosilybin A; 2,3-Dehydrosilibinin A; 3,5,7-Trihydroxy-2-[3-(4-hydroxy-3-methoxyphenyl)-2-(hydroxymethyl)-2,3-dihydro-1,4-benzodioxin-6-yl]-4-chromanone; (2R,3R)-2,3-Dihydro-2-(4-hydroxy-3-methoxyphenyl)-3-(hydroxymethyl)-7-[(2R,3R)-3,5,7-trihydroxy-4-oxo-2,3-dihydro-4H-chromen-2-yl]-1,4-benzodioxin-6-ol; A component of Silymarin
EINECS	Contact for details

Quality Control

Our 2,3-Dehydrosilybin A is produced under strict quality management protocols. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation (IR, MS), to ensure it meets the high standards required for research and development. Certificates of Analysis (COA) detailing batch-specific results are available upon request. We can support compliance needs for cGMP, ISO, and other relevant quality frameworks.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and easily oxidized; for long-term storage, consider storing under an inert atmosphere (e.g., nitrogen or argon) in a desiccated environment.

Specification

Item	Specification
Appearance	Yellow to light brown powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 95.0%
Loss on Drying	≤ 2.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.