Description

[1S-(1Alpha,4Beta,6Alpha)]-4,7,7-Trimethylbicyclo[4.1.0]Heptan-3-One is a high-purity, stereochemically defined bicyclic ketone, a key chiral intermediate in advanced organic synthesis. Its rigid, functionalized structure makes it an essential building block for creating complex molecules with precise three-dimensional architecture. This compound is particularly valuable for research and development in the pharmaceutical and fine chemical industries, where it is used to synthesize active pharmaceutical ingredients (APIs), fragrances, and specialty materials.

Application

• Pharmaceutical Intermediate: A critical chiral synthon for the synthesis of novel drug candidates, particularly in medicinal chemistry programs targeting central nervous system (CNS) and anti-inflammatory agents.
• Fragrance & Flavor Chemistry: Serves as a precursor for synthesizing unique terpenoid-derived aroma chemicals and musk analogs with complex olfactory profiles.
• Asymmetric Catalysis: Used as a ligand precursor or a chiral scaffold in the development of new catalysts for stereoselective transformations.
• Material Science Research: Employed in the development of specialty polymers and liquid crystals where its rigid, bicyclic structure imparts specific material properties.
• Organic Synthesis Building Block: Utilized in multi-step syntheses for natural product total synthesis and the construction of complex polycyclic frameworks.

Basic Information

Item	Detail
Product Name	[1S-(1Alpha,4Beta,6Alpha)]-4,7,7-Trimethylbicyclo[4.1.0]Heptan-3-One
CAS No.	24278-58-8
Molecular Formula	C10H16O
Molecular Weight	152.23 g/mol
Synonyms	(1S,4R,6R)-4,7,7-Trimethylbicyclo[4.1.0]heptan-3-one; (-)-3-Thujone; (1S,4R,6R)-3-Thujanone; (1S,4R,6R)-4,7,7-Trimethylnorcarane-3-one; L-(-)-3-Thujone; (1S,4R,6R)-Thujan-3-one; [1S-(1α,4β,6α)]-4,7,7-Trimethylbicyclo[4.1.0]heptan-3-one
EINECS	Contact for details

Quality Control

Every batch of [1S-(1Alpha,4Beta,6Alpha)]-4,7,7-Trimethylbicyclo[4.1.0]Heptan-3-One is manufactured and tested under a strict quality management system. We ensure high chiral purity and chemical consistency through advanced analytical techniques including chiral HPLC, GC, and NMR. A comprehensive Certificate of Analysis (COA) detailing identity, purity, enantiomeric excess, and impurity profiles is provided with each shipment to support your quality and regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). Keep away from strong oxidizing agents and incompatible materials.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC)	≥ 97.0%
Enantiomeric Excess (Chiral HPLC)	≥ 98.0%
Specific Rotation [α]	Contact for details
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.