Description

Trimethylsilyl (Trimethylsilyl)Acetate is a versatile organosilicon reagent primarily used as a silylating agent and a protective group intermediate in complex organic syntheses. Its core value lies in its ability to introduce the trimethylsilyl (TMS) group, which is crucial for protecting sensitive functional groups like alcohols and carboxylic acids during multi-step chemical processes. This compound is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and advanced materials sectors who require high-purity intermediates for developing active ingredients and specialty polymers.

Application

• Pharmaceutical Intermediate: Used as a key protecting group reagent in the synthesis of complex drug molecules and active pharmaceutical ingredients (APIs).
• Agrochemical Synthesis: Serves as a building block in the production of advanced pesticides, herbicides, and plant growth regulators.
• Peptide Chemistry: Employed for the protection of carboxylic acid groups during solid-phase and solution-phase peptide synthesis.
• Polymer & Material Science: Acts as a monomer or modifier in the synthesis of silicone-based polymers and specialty materials with tailored properties.
• Analytical Derivatization: Utilized to derivative polar compounds for Gas Chromatography (GC) and Gas Chromatography-Mass Spectrometry (GC-MS) analysis to improve volatility and detection.
• Organic Synthesis Reagent: A fundamental tool for chemists performing nucleophilic substitutions, esterifications, and other transformations requiring silyl group transfer.

Basic Information

Product Name	Trimethylsilyl (Trimethylsilyl)Acetate
CAS No.	24082-11-9
Molecular Formula	C8H18O2Si2
Molecular Weight	190.40 g/mol
Synonyms	Acetic Acid Trimethylsilyl Ester; (Trimethylsilyl)acetate; Trimethylsilyl Acetate; TMS Acetate; Acetoxytrimethylsilane; Trimethylsilyloxy Ethanal; (Acetoxy)trimethylsilane; Trimethylsilyl Acetic Acid Ester
EINECS	Contact for details

Quality Control

Our Trimethylsilyl (Trimethylsilyl)Acetate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including Gas Chromatography (GC) and Nuclear Magnetic Resonance (NMR) spectroscopy, to ensure high purity and consistency. We provide comprehensive Certificates of Analysis (COA) with every shipment, detailing all critical quality parameters. Our commitment to quality ensures the material meets the stringent requirements for research and industrial synthesis.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation from atmospheric moisture. Keep away from heat, sparks, and open flames.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms
Purity (GC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Refractive Index (n20D)	1.405 - 1.415
Density (g/mL at 20°C)	0.88 - 0.92

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.