Description

Kryptofix 222 is a specialized macrocyclic polyether, also known as a cryptand, with the CAS registry number 23978-09-8. This compound is a crucial phase-transfer catalyst and complexing agent, valued for its ability to selectively bind alkali metal cations and facilitate reactions in non-polar media. It is essential for researchers and manufacturers in pharmaceutical development, organic synthesis, and advanced materials science who require high-purity reagents for sensitive applications.

Application

• Phase-Transfer Catalysis (PTC): Enables reactions between reagents in immiscible phases, widely used in alkylation, esterification, and polymerization processes.
• Pharmaceutical Synthesis: Serves as a key reagent in the production of complex drug molecules, particularly in radiolabeling procedures for PET (Positron Emission Tomography) imaging agents like [18F]FDG.
• Organic & Organometallic Chemistry: Acts as a powerful complexing agent to solubilize inorganic salts in organic solvents, facilitating nucleophilic substitution and metal-halogen exchange reactions.
• Chemical Research: Used in supramolecular chemistry to create host-guest complexes and in the study of cation transport mechanisms.
• Materials Science: Employed in the synthesis and modification of polymers and in the preparation of specialized catalysts.
• Analytical Chemistry: Can be utilized as a selective masking agent in titrations and separations.

Basic Information

Item	Details
Product Name	Kryptofix 222
CAS No.	23978-09-8
Molecular Formula	C18H36N2O6
Molecular Weight	376.49 g/mol
Synonyms	4,7,13,16,21,24-Hexaoxa-1,10-diazabicyclo[8.8.8]hexacosane; Kryptofix® 222; K222; K-222; 2.2.2-Cryptand; Cryptand 222; [2.2.2]Cryptand; 1,10-Diaza-4,7,13,16,21,24-hexaoxabicyclo[8.8.8]hexacosane
EINECS	Contact for details

Quality Control

Our Kryptofix 222 is manufactured under strict quality systems to ensure batch-to-batch consistency and high purity suitable for sensitive synthetic applications. We provide comprehensive Certificates of Analysis (COA) with each batch, detailing purity, identity, and impurity profiles. While specific grades (e.g., for pharmaceutical research) are available, all material meets rigorous in-house specifications. Compliance with relevant guidelines for GMP and REACH is maintained throughout our supply chain.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals (as Pb)	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.