Description

(-)-4',4''',5,5'',7''-Pentahydroxy-7-Methoxy-6,8''-Biflavone CAS NO 22973-14-4 is a high-purity, naturally derived biflavonoid compound. This specialized phytochemical is valued for its distinct stereochemistry and complex polyphenolic structure, which underpins its biological activity. It serves as a critical reference standard and active ingredient for research and development in the pharmaceutical, nutraceutical, and cosmeceutical industries.

Application

• Pharmaceutical Research: Used as a reference standard and active pharmaceutical ingredient (API) intermediate in the development of anti-inflammatory, antioxidant, and neuroprotective therapeutics.
• Nutraceutical Formulation: Incorporated into advanced dietary supplements targeting oxidative stress and metabolic health due to its potent bioflavonoid profile.
• Cosmetic Science: Serves as a key bioactive component in premium skincare formulations for its potential anti-aging and skin-protectant properties.
• Biochemical Research: Employed in enzymatic studies, cell-based assays, and as a probe to investigate specific biochemical pathways and receptor interactions.
• Analytical Chemistry: Essential as a certified reference material (CRM) for method development, validation, and quality control in HPLC and LC-MS analysis.

Basic Information

Product Name	(-)-4',4''',5,5'',7''-Pentahydroxy-7-Methoxy-6,8''-Biflavone
CAS No.	22973-14-4
Molecular Formula	C₃₁H₂₀O₁₁
Molecular Weight	568.48 g/mol
Synonyms	(-)-Amentoflavone 7-Methyl Ether; 7-O-Methylamentoflavone; 7-Methoxyamentoflavone; (-)-7-Methoxyamentoflavone; 6,8''-Biflavone, 4',4''',5,5'',7''-pentahydroxy-7-methoxy-; (2S)-2-[5-Hydroxy-2-(4-hydroxyphenyl)-4-oxochromen-7-yl]-5,7-dihydroxy-8-[5-hydroxy-2-(4-hydroxyphenyl)-4-oxochromen-7-yl]-6-methoxychromen-4-one
EINECS	Contact for details

Quality Control

Our (-)-4',4''',5,5'',7''-Pentahydroxy-7-Methoxy-6,8''-Biflavone is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing including HPLC for purity, NMR and MS for structural confirmation, and residual solvent analysis. Certificates of Analysis (COA) detailing all specifications are provided to ensure traceability and compliance with your research or cGMP requirements.

Storage

Preserve in a tightly closed container, protected from light. Store under inert atmosphere at -20°C or below for long-term stability. For daily use, allow the sealed container to equilibrate to room temperature before opening to prevent moisture condensation. Keep container tightly sealed in a cool, dry, and well-ventilated place.

Specification

Item	Specification
Appearance	Yellow to light brown powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥95.0%
Loss on Drying	≤2.0%
Residue on Ignition	≤0.5%
Heavy Metals (as Pb)	≤20 ppm
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.