Description

trans-2-(Hydroxymethyl)-1-Phenylcyclopropanecarboxylic Acid is a versatile chiral cyclopropane derivative, a key structural motif in medicinal chemistry and advanced organic synthesis. This compound matters as a high-value building block for the development of novel active pharmaceutical ingredients (APIs) and fine chemicals, offering a rigid, three-dimensional scaffold. Pharmaceutical R&D laboratories and fine chemical manufacturers need it for creating potent drug candidates, particularly in therapeutic areas targeting the central nervous system and metabolic diseases.

Application

• Pharmaceutical Intermediate: A critical chiral synthon for the synthesis of novel drug candidates, especially protease inhibitors and neuromodulators.
• Asymmetric Synthesis Building Block: Utilized in stereoselective reactions to construct complex molecules with defined three-dimensional architecture.
• Medicinal Chemistry Research: Serves as a core scaffold in structure-activity relationship (SAR) studies for new therapeutic agents.
• Ligand and Catalyst Development: Used in the preparation of chiral ligands and organocatalysts for enantioselective transformations.
• Fine Chemical Production: Incorporated into the manufacture of specialty chemicals requiring the cyclopropane pharmacophore.
• Academic & Industrial R&D: A valuable compound for research in organic methodology and the exploration of new chemical space.

Basic Information

Product Name	trans-2-(Hydroxymethyl)-1-Phenylcyclopropanecarboxylic Acid
CAS No.	22613-99-6
Molecular Formula	C11H12O3
Molecular Weight	192.21 g/mol
Synonyms	(1R,2S)-rel-2-(Hydroxymethyl)-1-phenylcyclopropanecarboxylic Acid; (1S,2R)-rel-2-(Hydroxymethyl)-1-phenylcyclopropanecarboxylic Acid; trans-1-Phenyl-2-(hydroxymethyl)cyclopropanecarboxylic Acid; (±)-trans-2-(Hydroxymethyl)-1-phenylcyclopropanecarboxylic Acid; rac-trans-2-(Hydroxymethyl)-1-phenylcyclopropanecarboxylic Acid; 1-Phenyl-2-(hydroxymethyl)cyclopropanecarboxylic Acid; Cyclopropanecarboxylic acid, 2-(hydroxymethyl)-1-phenyl-, trans-
EINECS	Contact for details

Quality Control

Our trans-2-(Hydroxymethyl)-1-Phenylcyclopropanecarboxylic Acid is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification, to ensure it meets the high standards required for pharmaceutical R&D and fine chemical synthesis. Certificates of Analysis (COA) with detailed chromatographic data (HPLC, GC) are provided to guarantee consistent quality, identity, and purity for your critical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); therefore, the container must be kept tightly sealed to minimize exposure to atmospheric humidity. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% de (trans-isomer)
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.