Description

(1R,3S)-3-Acetyl-2,2-Dimethylcyclobutane-Carboxylic Acid CAS NO 22571-78-4 is a high-purity, chiral cyclobutane derivative that serves as a critical advanced pharmaceutical intermediate and building block for complex organic synthesis. Its unique sterically constrained structure and functional groups make it invaluable for constructing molecules with specific three-dimensional architectures. This compound is primarily sought after by pharmaceutical R&D and fine chemical synthesis teams for developing novel active ingredients and specialty materials.

Application

• Pharmaceutical Intermediate: Key chiral precursor in the synthesis of proprietary drug candidates, particularly in therapeutic areas requiring complex, constrained molecular frameworks.
• Asymmetric Synthesis: Serves as a building block for constructing other chiral molecules, leveraging its defined (1R,3S) stereochemistry.
• Fragrance & Flavor Chemistry: Potential intermediate for creating novel synthetic musks or flavor compounds with unique olfactory properties derived from the cyclobutane ring.
• Agrochemical Research: Used in developing new active ingredients for crop protection, where the dimethylcyclobutane moiety can impart favorable biological activity and stability.
• Material Science: Monomer or precursor for specialty polymers and advanced materials requiring rigid, aliphatic components.
• Academic & Industrial R&D: A valuable reagent for methodological studies in organic chemistry, including ring-opening, functionalization, and cross-coupling reactions.

Basic Information

Product Name	(1R,3S)-3-Acetyl-2,2-Dimethylcyclobutane-Carboxylic Acid
CAS No.	22571-78-4
Molecular Formula	C9H14O3
Molecular Weight	170.21 g/mol
Synonyms	(1R,3S)-3-Acetyl-2,2-dimethylcyclobutanecarboxylic acid; (-)-3-Acetyl-2,2-dimethylcyclobutanecarboxylic acid; (1R-cis)-3-Acetyl-2,2-dimethylcyclobutanecarboxylic Acid; 2,2-Dimethyl-3-acetylcyclobutanecarboxylic acid; cis-3-Acetyl-2,2-dimethylcyclobutanecarboxylic acid; Cyclobutanecarboxylic acid, 3-acetyl-2,2-dimethyl-, (1R,3S)-; (1R,3S)-rel-3-Acetyl-2,2-dimethylcyclobutanecarboxylic Acid
EINECS	Contact for details

Quality Control

Our (1R,3S)-3-Acetyl-2,2-Dimethylcyclobutane-Carboxylic Acid is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity assay and impurity profiling, to ensure it meets the stringent requirements for pharmaceutical R&D. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting identity, purity, and enantiomeric excess.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to exclude moisture. Keep away from incompatible materials such as strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Assay (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.