Description

3-Cyclobutene-1,2-Dione, 3-Bromo- is a specialized brominated derivative of squaric acid, serving as a versatile and reactive synthetic intermediate. Its unique cyclobutenedione core functionalized with a bromine atom makes it a valuable building block for constructing complex molecular architectures, particularly in pharmaceutical and advanced material research. This compound is primarily sought by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for synthesizing novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel drug candidates, especially those containing heterocyclic or strained ring systems.
• Agrochemical Synthesis: Used in the research and development of new herbicides, fungicides, and plant growth regulators.
• Material Science Research: Serves as a precursor for creating organic electronic materials, dyes, and pigments with specific optical properties.
• Cross-Coupling Reactions: The bromine substituent makes it a suitable substrate for palladium-catalyzed reactions like Suzuki or Sonogashira couplings to introduce the cyclobutenedione moiety.
• Ligand and Catalyst Development: Used to synthesize novel chelating ligands or organocatalysts for asymmetric synthesis.
• Academic & Institutional Research: A valuable reagent for methodological studies in organic chemistry and exploring new reaction pathways.

Basic Information

Product Name	3-Cyclobutene-1,2-Dione, 3-Bromo-
CAS No.	22557-51-3
Molecular Formula	C4HBrO2
Molecular Weight	160.95 g/mol
Synonyms	3-Bromocyclobut-3-ene-1,2-dione; 3-Bromosquaric Acid; 3-Bromo-1,2-cyclobutenedione; Bromosquarate; 3-Bromo-3,4-dihydroxycyclobut-3-ene-1,2-dione (tautomer); 3-Bromo-1,2-dihydroxycyclobut-3-ene-1,2-dione; 3-Bromocyclobutenedione
EINECS	Contact for details

Quality Control

Our 3-Bromosquaric Acid is produced under strict quality management protocols. Each batch undergoes comprehensive analytical testing, including HPLC for purity and NMR for structural confirmation, to ensure it meets the high standards required for research and development. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting key parameters such as assay, identity, and impurity profiles. We support cGMP and ISO 9001 compliant manufacturing practices for traceability and consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). The compound is light-sensitive and should be handled under appropriate conditions to maintain stability. Keep away from incompatible materials such as strong bases and reducing agents.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Melting Point	Contact for details
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.