Description

Bicyclo[1.1.1]pentan-3-amine, hydrochloride is a high-value, structurally constrained amine building block essential for modern drug discovery and materials science. Its unique [1.1.1]propellane-derived scaffold enables the synthesis of novel, three-dimensional molecular architectures with improved physicochemical properties. This compound is primarily sought after by pharmaceutical R&D teams and advanced chemical manufacturers developing next-generation active pharmaceutical ingredients (APIs), agrochemicals, and specialty polymers.

Application

• Pharmaceutical Intermediates: A key synthon for introducing the rigid bicyclo[1.1.1]pentane (BCP) bioisostere into drug candidates, potentially improving metabolic stability, solubility, and target selectivity.
• Agrochemical Research: Used in the development of novel herbicides, fungicides, and insecticides where the BCP core can enhance biological activity and environmental profile.
• Materials Science: Serves as a precursor for cross-linked polymers, high-performance resins, and advanced materials requiring rigid, three-dimensional linkers.
• Chemical Biology & Proteomics: Employed as a building block for affinity probes, photo-crosslinkers, and other tools for studying protein-ligand interactions.
• Ligand Synthesis for Catalysis: Used to create novel, sterically demanding ligands for transition metal catalysis.
• Academic & Industrial R&D: A fundamental reagent for methodological development in organic synthesis and medicinal chemistry.

Basic Information

Product Name	Bicyclo[1.1.1]pentan-3-amine, hydrochloride
CAS No.	22287-35-0
Molecular Formula	C5H10ClN
Molecular Weight	119.59 g/mol
Synonyms	3-Aminobicyclo[1.1.1]pentane hydrochloride; 1-Aminobicyclo[1.1.1]pentane hydrochloride; BCP-NH2·HCl; Bicyclo[1.1.1]pentan-1-amine hydrochloride; [1.1.1]Propellane-3-amine hydrochloride; 3-Amino[1.1.1]propellane hydrochloride
EINECS	Contact for details

Quality Control

Our Bicyclo[1.1.1]pentan-3-amine, hydrochloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure high chemical purity and structural identity. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere or in a dry environment to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Assay (Titration)	95.0 - 105.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.