Description

4-Ethynylphenyl Ether is a specialized aromatic ether building block featuring a terminal alkyne functional group. This unique molecular structure makes it a valuable intermediate for advanced organic synthesis, particularly in the construction of complex molecules and functional materials. It is primarily utilized by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and materials science industries for applications such as click chemistry, cross-coupling reactions, and polymer synthesis.

Application

• Pharmaceutical Intermediate: Serves as a key synthon in the development of active pharmaceutical ingredients (APIs) via Sonogashira coupling and other metal-catalyzed reactions.
• Agrochemical Synthesis: Used in the research and production of novel crop protection agents and herbicides.
• Material Science & Polymer Chemistry: Acts as a monomer or cross-linking agent for creating specialty polymers, dendrimers, and advanced organic frameworks with tailored properties.
• Click Chemistry Reagent: The terminal alkyne group enables efficient Huisgen 1,3-dipolar cycloaddition (azide-alkyne click chemistry) for bioconjugation and material surface functionalization.
• Liquid Crystal & OLED Research: Employed as a building block for synthesizing organic semiconductors and liquid crystal materials for electronic displays.
• Chemical Biology Probes: Useful for tagging biomolecules or creating fluorescent probes for diagnostic and research applications.

Basic Information

Item	Details
Product Name	4-Ethynylphenyl Ether
CAS No.	21368-80-9
Molecular Formula	C8H6O
Molecular Weight	118.13 g/mol
Synonyms	1-Ethynyl-4-phenoxybenzene; 4-Phenoxyphenylacetylene; p-Ethynylphenyl phenyl ether; 4-Phenoxybenzeneacetylene; 1-Ethynyl-4-phenoxy-benzene; (4-Phenoxyphenyl)acetylene; 4-(Phenoxy)phenylacetylene
EINECS	Contact for details

Quality Control

Our 4-Ethynylphenyl Ether is produced under a strict quality management system. Each batch undergoes comprehensive analytical testing, including HPLC, GC, and NMR, to ensure high purity and consistency. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with every shipment. We support cGMP compliance for pharmaceutical applications and can tailor specifications to meet specific project requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). This compound is light-sensitive (store away from light) and should be handled under an inert atmosphere for long-term storage to prevent potential oxidation of the alkyne moiety.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.