Description

(2R-Trans)-2-[3,4-Bis(Phenylmethoxy)Phenyl]-3,4-Dihydro-5,7-Bis(Phenylmethoxy)-2H-1-Benzopyran-3-Ol is a high-purity, stereochemically defined chroman derivative that serves as a critical advanced intermediate in organic synthesis. Its complex structure, featuring multiple protected phenolic groups, makes it a valuable building block for the research and development of novel pharmaceutical compounds and fine chemicals. This product is essential for R&D chemists and process development scientists working in medicinal chemistry, particularly in the synthesis of complex natural product analogs and targeted bioactive molecules.

Application

• Pharmaceutical Intermediate: Key chiral building block in the synthesis of potential drug candidates, especially those with chroman or flavan-based scaffolds.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and for constructing complex molecular libraries for high-throughput screening.
• Process Chemistry Development: Serves as a standardized intermediate for scaling up synthetic routes under Good Manufacturing Practice (GMP) conditions.
• Fine Chemical Synthesis: Intermediate for producing specialized chemicals used in agrochemicals, dyes, and functional materials.
• Academic & Institutional Research: A valuable reagent for universities and research institutes studying synthetic methodology, natural product synthesis, and asymmetric catalysis.

Basic Information

Item	Detail
Product Name	(2R-Trans)-2-[3,4-Bis(Phenylmethoxy)Phenyl]-3,4-Dihydro-5,7-Bis(Phenylmethoxy)-2H-1-Benzopyran-3-Ol
CAS No.	20728-73-8
Molecular Formula	C43H38O6
Molecular Weight	650.76 g/mol
Synonyms	(2R-trans)-5,7-Bis(benzyloxy)-2-[3,4-bis(benzyloxy)phenyl]-3,4-dihydro-2H-1-benzopyran-3-ol; (2R,3S)-5,7-Bis-O-benzyl-2-(3,4-bis-O-benzylphenyl)-3,4-dihydro-2H-chromen-3-ol; NSC 407303; Chroman-3-ol derivative; 2H-1-Benzopyran-3-ol, 2-[3,4-bis(phenylmethoxy)phenyl]-3,4-dihydro-5,7-bis(phenylmethoxy)-, (2R-trans)-
EINECS	Contact for details

Quality Control

Our (2R-Trans)-2-[3,4-Bis(Phenylmethoxy)Phenyl]-3,4-Dihydro-5,7-Bis(Phenylmethoxy)-2H-1-Benzopyran-3-Ol is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high chemical purity. Each lot is characterized using advanced analytical techniques including HPLC, NMR, and chiral analysis to confirm identity, purity, and stereochemical integrity. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The compound is light-sensitive; prolonged exposure to light should be avoided to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.