Description

4-Bromo-2,5-Dihydro-1-(p-Tolylsulfonyl)-1H-1-Benzazepin-5-One is a high-purity, advanced pharmaceutical intermediate characterized by its unique benzazepinone core structure. This compound is of significant value for its role as a key synthetic building block in the development of novel active pharmaceutical ingredients (APIs). It is primarily sought after by research institutions and pharmaceutical manufacturers engaged in medicinal chemistry, particularly for projects involving central nervous system (CNS) agents and other therapeutic small molecules. Our supply ensures consistent quality and reliable availability for critical R&D and scale-up processes.

Application

• Pharmaceutical Intermediate: A crucial precursor in the multi-step synthesis of complex drug candidates and novel therapeutic agents.
• Medicinal Chemistry Research: Used as a scaffold or building block for structure-activity relationship (SAR) studies and lead optimization in drug discovery programs.
• Organic Synthesis: Serves as a versatile reagent for constructing benzazepinone derivatives and other fused heterocyclic systems of interest.
• Contract Research & Manufacturing (CRO/CMO): Supplied to organizations specializing in custom synthesis and process development for the pharmaceutical industry.
• Academic Research: Utilized in university and institutional labs for studying synthetic methodologies and reaction mechanisms involving sulfonamide-protected nitrogen heterocycles.

Basic Information

Product Name	4-Bromo-2,5-Dihydro-1-(p-Tolylsulfonyl)-1H-1-Benzazepin-5-One
CAS No.	20426-62-4
Molecular Formula	C17H14BrNO3S
Molecular Weight	392.27 g/mol
Synonyms	4-Bromo-1-(4-methylphenyl)sulfonyl-2,5-dihydro-1H-1-benzazepin-5-one; 4-Bromo-2,3-dihydro-1-tosyl-1H-1-benzazepin-5(4H)-one; 1-(4-Methylbenzenesulfonyl)-4-bromo-2,5-dihydro-1H-1-benzazepin-5-one; 4-Bromo-1-tosyl-2,5-dihydro-1H-1-benzazepin-5-one; 4-Bromo-1-tosyl-1,2-dihydro-5H-1-benzazepin-5-one; 4-Bromo-2,5-dihydro-1-tosyl-1H-1-benzazepin-5-one; 4-Bromo-1-(p-tolylsulfonyl)-2,5-dihydro-1H-1-benzazepin-5-one
EINECS	Contact for details

Quality Control

Our production of 4-Bromo-2,5-Dihydro-1-(p-Tolylsulfonyl)-1H-1-Benzazepin-5-One adheres to stringent quality management protocols. Each batch undergoes rigorous analytical testing, including HPLC for purity assessment and NMR/IR for structural confirmation, to ensure compliance with exacting standards for pharmaceutical intermediates. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to guarantee traceability and support your quality assurance processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at controlled room temperature (15-25°C). Keep the container tightly sealed in a dry environment to maintain product integrity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.