Description

(2R,2'R,3S,3'S,4S,4'R)-3,3',4,4'-Tetrahydro-2,2'-Bis(3,4-Dihydroxyphenyl)-4,6'-Bi[2H-1-Benzopyran]-3,3',4',7,7'-Pentol is a complex polyphenolic compound belonging to the biflavonoid class, known for its potent antioxidant and bioactive properties. This high-purity chemical is critical for research and development in advanced life sciences due to its specific stereochemistry and biological activity. It is primarily sought by pharmaceutical researchers, nutraceutical formulators, and analytical laboratories for use in drug discovery, natural product standardization, and biochemical studies.

Application

• Pharmaceutical Reference Standard: Used as a certified reference material (CRM) for the identification, assay, and purity testing of related natural products and complex APIs in QC/QA laboratories.
• Bioactive Ingredient Research: Serves as a key intermediate or active component in preclinical studies targeting oxidative stress, inflammation, and metabolic disorders.
• Nutraceutical Development: Incorporated into high-end dietary supplement formulations for its antioxidant potential, requiring strict quality control for efficacy and safety.
• Analytical Chemistry: Employed as a calibration standard in advanced chromatographic (HPLC, LC-MS) and spectroscopic methods for quantifying flavonoids in plant extracts.
• Life Science Reagents: Used in biochemical assays and cell culture studies to investigate specific signaling pathways and cellular mechanisms.
• Cosmeceutical Actives: Potential application in premium skincare products for its antioxidant and skin-protective properties.

Basic Information

Item	Detail
Product Name	(2R,2'R,3S,3'S,4S,4'R)-3,3',4,4'-Tetrahydro-2,2'-Bis(3,4-Dihydroxyphenyl)-4,6'-Bi[2H-1-Benzopyran]-3,3',4',7,7'-Pentol
CAS No.	20254-30-2
Molecular Formula	C30H24O12
Molecular Weight	576.5 g/mol
Synonyms	Amentoflavone; 3',8''-Biapigenin; 4',6''-Biapigenin; 8,8''-Biapigenin; 4',6'-Biapigenin; 5,5'',7,7''-Tetrahydroxy-2,2''-bis(4-hydroxyphenyl)-4H,4''H-[3,8''-bichromene]-4,4''-dione (tautomeric form); Bioflavonoid; Biflavonoid; IUPAC: 8-[5-(5,7-dihydroxy-4-oxochromen-2-yl)-2-hydroxyphenyl]-5,7-dihydroxy-2-(4-hydroxyphenyl)chromen-4-one
EINECS	Contact for details

Quality Control

Our (2R,2'R,3S,3'S,4S,4'R)-3,3',4,4'-Tetrahydro-2,2'-Bis(3,4-Dihydroxyphenyl)-4,6'-Bi[2H-1-Benzopyran]-3,3',4',7,7'-Pentol is manufactured under a strict quality management system. Each batch undergoes comprehensive analytical testing including HPLC for purity, chiral analysis for stereochemical integrity, and identity confirmation via NMR and MS. Certificates of Analysis (COA) detailing all specifications and test results are provided and can be tailored to meet specific pharmacopeial or internal standards upon request.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) at a controlled room temperature (15-25°C) in a dry environment. This compound is easily oxidized and light-sensitive; prolonged exposure to air, moisture, or light will lead to degradation.

Specification

Item	Specification
Appearance	Yellow to light brown powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 95.0%
Chiral Purity	≥ 98.0% (by Chiral HPLC)
Water Content (KF)	≤ 2.0%
Residue on Ignition	≤ 0.5%
Heavy Metals (as Pb)	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.