Description

1,6-Anhydro-2,4-Di-o-p-Toluenesulfonyl-β-D-Glucopyranose is a key protected carbohydrate derivative, specifically a 1,6-anhydro sugar with tosyl groups at the 2 and 4 positions. This compound serves as a versatile and critical chiral building block in advanced organic synthesis, enabling precise stereochemical control. It is primarily utilized by research chemists and process development scientists in the pharmaceutical and fine chemical industries for the synthesis of complex glycosides, nucleoside analogs, and other bioactive molecules.

Application

• Pharmaceutical Intermediate: A crucial precursor in the multi-step synthesis of novel antiviral agents, antibiotics, and other therapeutic compounds requiring specific sugar-based scaffolds.
• Glycochemistry Research: Used in academic and industrial R&D for studying glycosylation reactions, enzyme mechanisms, and carbohydrate-protein interactions.
• Nucleoside Analog Synthesis: Serves as a protected sugar donor for the construction of modified nucleosides with potential applications in medicinal chemistry and diagnostics.
• Chiral Auxiliary & Ligand Preparation: The rigid 1,6-anhydro bridge and defined stereochemistry make it a valuable starting material for developing chiral catalysts and ligands for asymmetric synthesis.
• Fine Chemical Production: Employed in the custom synthesis of specialty chemicals, flavors, and fragrances where specific sugar derivatives are required.

Basic Information

Product Name	1,6-Anhydro-2,4-Di-o-p-Toluenesulfonyl-β-D-Glucopyranose
CAS No.	20204-80-2
Molecular Formula	C₂₀H₂₂O₉S₂
Molecular Weight	470.51 g/mol
Synonyms	1,6-Anhydro-2,4-di-O-(p-toluenesulfonyl)-β-D-glucopyranose; 2,4-Di-O-tosyl-1,6-anhydro-β-D-glucopyranose; Levoglucosan 2,4-ditosylate; 1,6-Anhydro-2,4-di-O-tosyl-β-D-glucose; 2,4-Di-O-(4-methylbenzenesulfonyl)-1,6-anhydro-β-D-glucopyranose; β-D-Glucopyranose, 1,6-anhydro-2,4-bis-O-(4-methylphenyl)sulfonyl]-
EINECS	Contact for details

Quality Control

Our 1,6-Anhydro-2,4-Di-o-p-Toluenesulfonyl-β-D-Glucopyranose is produced under strict quality management protocols. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR for structural confirmation, and chiral analysis to ensure stereochemical integrity. We provide a detailed Certificate of Analysis (COA) with every shipment, documenting key parameters such as assay, identity, and impurity profiles to support your regulatory and research requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (typically 15-25°C). The compound may be moisture-sensitive; keep the container tightly sealed when not in use. For long-term storage, consider inert atmosphere conditions to maintain optimal stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Specific Rotation	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.