Description

3,5-Dichloro-4-Fluorophenol is a halogenated phenol derivative that serves as a versatile and critical building block in advanced organic synthesis. Its unique substitution pattern makes it a valuable intermediate for constructing complex molecules, particularly in the pharmaceutical and agrochemical sectors. This compound is essential for researchers and manufacturers developing active ingredients, specialty chemicals, and functional materials where precise halogenation is required for bioactivity or material properties.

Application

• Pharmaceutical Intermediate: Key synthon for the production of active pharmaceutical ingredients (APIs), especially in the synthesis of antibacterial and antifungal agents.
• Agrochemical Synthesis: Used in the manufacture of herbicides, fungicides, and pesticides, where the dichloro-fluorophenol moiety contributes to product efficacy.
• Liquid Crystal & Polymer Chemistry: Serves as a monomer or precursor for specialty polymers and liquid crystal materials due to its rigid, halogenated aromatic structure.
• Dyestuff & Pigment Intermediate: Employed in the synthesis of complex dyes and organic pigments, providing color fastness and stability.
• Research & Development: A valuable reagent in academic and industrial R&D for exploring new chemical entities and reaction pathways.
• Cross-Coupling Reactions: Acts as a substrate in palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Buchwald-Hartwig) to form biaryl structures.

Basic Information

Product Name	3,5-Dichloro-4-Fluorophenol
CAS No.	2995-04-2
Molecular Formula	C6H3Cl2FO
Molecular Weight	180.99 g/mol
Synonyms	4-Fluoro-3,5-dichlorophenol; 3,5-Dichloro-4-fluorophenol; Phenol, 3,5-dichloro-4-fluoro-; 3,5-Dichloro-4-hydroxyfluorobenzene; 2,6-Dichloro-4-fluorophenol; 4-Fluoro-2,6-dichlorophenol; NSC 406106; FDC
EINECS	221-073-6

Quality Control

Our 3,5-Dichloro-4-Fluorophenol is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high purity and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specifications. Our quality commitment ensures the material is suitable for demanding applications in cGMP-compliant pharmaceutical synthesis and other high-value industries.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Due to its light-sensitive nature and propensity to be easily oxidized, it is recommended to store the material under an inert atmosphere (e.g., nitrogen or argon) for long-term preservation. Keep away from strong oxidizing agents, strong bases, and heat sources.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Melting Point	68 - 72 °C
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals (as Pb)	≤ 20 ppm
Related Substances (HPLC)	Total impurities ≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.