Description

3-Chlorosulfonyl-4-Methyl-Benzoic Acid is a versatile and high-value aromatic sulfonyl chloride derivative, serving as a critical building block in advanced organic synthesis. Its bifunctional nature, featuring both a reactive sulfonyl chloride group and a carboxylic acid moiety, makes it indispensable for constructing complex molecular architectures. This compound is primarily sought after by research institutions and manufacturers in the pharmaceutical and agrochemical sectors for the development of active ingredients and specialty chemicals.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of sulfonamide-based drugs, including diuretics, carbonic anhydrase inhibitors, and antiviral agents.
• Agrochemical Synthesis: Used in the production of herbicides, fungicides, and plant growth regulators that require the sulfonyl group for bioactivity.
• Dyestuff and Pigment Manufacturing: Serves as an intermediate for creating sulfonated azo dyes and high-performance pigments.
• Polymer Modification: Employed to introduce sulfonyl chloride functionalities into polymer chains for creating ion-exchange resins or specialty coatings.
• Chemical Research & Development: A valuable reagent in medicinal chemistry and material science for exploring new chemical entities and functional materials.
• Cross-coupling Reactions: The reactive sites facilitate Suzuki, Sonogashira, and other palladium-catalyzed coupling reactions to create complex biaryl structures.

Basic Information

Product Name	3-Chlorosulfonyl-4-Methyl-Benzoic Acid
CAS No.	2548-29-0
Molecular Formula	C8H7ClO4S
Molecular Weight	234.66 g/mol
Synonyms	4-Methyl-3-sulfonylchloride-benzoic acid; 3-(Chlorosulfonyl)-4-methylbenzoic acid; 4-Methyl-3-chlorosulfonylbenzoic acid; Benzoic acid, 3-(chlorosulfonyl)-4-methyl-; 3-Carboxy-6-methylbenzenesulfonyl chloride; 2-Methyl-5-carboxybenzenesulfonyl chloride; 4-Methyl-3-sulfobenzoic acid chloride
EINECS	219-826-6

Quality Control

Our production of 3-Chlorosulfonyl-4-Methyl-Benzoic Acid adheres to stringent quality management protocols to ensure batch-to-batch consistency and high purity. Each lot is analyzed using advanced techniques including HPLC, NMR, and titration to confirm identity, potency, and impurity profiles. A comprehensive Certificate of Analysis (COA) detailing all test results is provided with every shipment, ensuring full traceability and compliance with customer specifications and cGMP guidelines where applicable.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from heat, open flames, and incompatible materials such as strong bases and amines.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.