Description

(2R,3R,4R,5R)-1,6-Bis(Methylsulfonyloxy)Hexane-2,3,4,5-Tetrol is a high-purity, stereochemically defined mesylate derivative of a hexitol sugar alcohol. This compound serves as a critical advanced pharmaceutical intermediate (API intermediate) and a versatile chiral building block for complex organic synthesis. It is primarily required by pharmaceutical R&D and fine chemical manufacturers engaged in the development of nucleoside analogs, prodrugs, and other bioactive molecules where precise stereochemistry is essential.

Application

• Pharmaceutical Intermediate: Key chiral precursor in the synthesis of novel antiviral and anticancer nucleoside analogs.
• Prodrug Synthesis: Used to introduce mesylate protecting groups or as a linker in prodrug strategies to enhance drug solubility and bioavailability.
• Carbohydrate Chemistry: Serves as a protected, activated sugar derivative for the construction of complex oligosaccharides or glycomimetics.
• Chiral Pool Synthesis: Provides a source of defined (2R,3R,4R,5R) stereochemistry for the asymmetric synthesis of natural products and specialty chemicals.
• Chemical Biology Research: Utilized in the development of molecular probes, enzyme inhibitors, and other tools where a polyhydroxylated scaffold is needed.
• Polymer Science: Potential monomer or cross-linking agent for creating functionalized, hydrophilic polymers.

Basic Information

Item	Detail
Product Name	(2R,3R,4R,5R)-1,6-Bis(Methylsulfonyloxy)Hexane-2,3,4,5-Tetrol
CAS No.	2514-83-2
Molecular Formula	C8H18O10S2
Molecular Weight	338.35 g/mol
Synonyms	1,6-Di-O-mesyl-D-mannitol; D-Mannitol 1,6-Dimesylate; 1,6-Bis-O-(methylsulfonyl)-D-mannitol; Hexane-2,3,4,5-tetrol, 1,6-bis(methylsulfonyloxy)-, (2R,3R,4R,5R)-; D-Mannitol dimethanesulfonate; (2R,3R,4R,5R)-Hexane-1,2,3,4,5,6-hexol 1,6-dimesylate
EINECS	Contact for details

Quality Control

We supply (2R,3R,4R,5R)-1,6-Bis(Methylsulfonyloxy)Hexane-2,3,4,5-Tetrol in high-purity grades suitable for research and cGMP manufacturing. Our products undergo rigorous quality testing including chiral purity analysis (HPLC, optical rotation) and identity confirmation (NMR, MS) to ensure compliance with stringent industry standards. A comprehensive Certificate of Analysis (COA) is provided with each batch, detailing purity, chiral excess, and impurity profiles.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); therefore, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.