Description

H-Orn(Boc)-Ome Hcl is a protected amino acid derivative, specifically the hydrochloride salt of Nα-Boc-O-methyl-L-ornithine. This compound is a critical building block in solid-phase peptide synthesis (SPPS), enabling the controlled incorporation of ornithine residues while preventing unwanted side reactions. It is essential for researchers and manufacturers in the pharmaceutical and biotechnology sectors developing novel peptide-based therapeutics, diagnostics, and research biochemicals. Its high purity and stability are paramount for ensuring the success and reproducibility of complex peptide assembly.

Application

• Peptide Synthesis: A fundamental reagent for the stepwise construction of peptides containing ornithine, particularly in Fmoc/t-Bu and Boc/Bzl strategies.
• Pharmaceutical Intermediates: Serves as a key intermediate in the research and development of peptide drugs targeting various diseases.
• Bioconjugation: The ornithine side chain, after deprotection, provides a primary amine handle for linking peptides to other molecules, such as dyes, polymers, or solid supports.
• Chemical Biology Research: Used in the study of protein-protein interactions, enzyme substrates, and the development of peptide mimetics.
• API Development: Employed in the process development and scale-up of Active Pharmaceutical Ingredients (APIs) with ornithine motifs.

Basic Information

Product Name	H-Orn(Boc)-Ome Hcl
CAS No.	2480-96-8
Molecular Formula	C11H22N2O4 • HCl
Molecular Weight	282.76 g/mol (Free base: 246.30)
Synonyms	Nα-Boc-O-methyl-L-ornithine hydrochloride; (S)-2-((tert-Butoxycarbonyl)amino)-5-(methoxyamino)pentanoic acid hydrochloride; Boc-Orn(OMe)-OH • HCl; Boc-L-Orn(OMe)-OH • HCl; H-Orn(Boc)-OMe • HCl; N-Boc-O-methyl-L-ornithine HCl; Nα-(tert-Butoxycarbonyl)-O-methyl-L-ornithine hydrochloride
EINECS	Contact for details

Quality Control

Our H-Orn(Boc)-Ome Hcl is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis for enantiomeric excess, and NMR for structural confirmation, to ensure it meets the high standards required for peptide synthesis. Certificates of Analysis (COA) with detailed chromatographic data are provided to guarantee traceability, consistency, and compliance with your research or cGMP guidelines.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as specified on the label or COA. This product is hygroscopic (moisture-sensitive); ensure the container is kept sealed in a desiccated environment to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Optical Rotation	[α]D20: Contact for details
Chiral Purity (HPLC)	≥99.0%
Water Content (KF)	≤1.0%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.