Description

4-Chlorobutyramide is a versatile chlorinated amide compound that serves as a crucial synthetic intermediate in organic chemistry. Its value lies in its bifunctional reactivity, featuring both an electrophilic chloroalkyl group and a nucleophilic amide moiety, enabling its use in the construction of more complex heterocyclic and pharmaceutical structures. This makes it an essential building block for research and development chemists, particularly in the pharmaceutical, agrochemical, and specialty chemical industries seeking to synthesize pyrrolidinones, peptides, or other nitrogen-containing target molecules.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of various active pharmaceutical ingredients (APIs), including GABAergic agents and neurological drugs.
• Agrochemical Synthesis: Used in the production of herbicides, fungicides, and plant growth regulators that require a chlorobutyl backbone.
• Heterocyclic Chemistry: Fundamental building block for the preparation of nitrogen-containing heterocycles such as pyrrolidinones and piperidines via intramolecular cyclization reactions.
• Polymer & Material Science: Serves as a monomer or cross-linking agent in the development of specialty polyamides and functional polymers.
• Peptide Mimetics & Biochemistry: Employed in the synthesis of peptide analogs and biochemical probes where the chlorobutyl side chain is incorporated.
• Organic Synthesis Research: A valuable reagent in academic and industrial R&D for exploring new carbon-nitrogen bond-forming reactions and cascade processes.

Basic Information

Product Name	4-Chlorobutyramide
CAS No.	2455-04-1
Molecular Formula	C4H8ClNO
Molecular Weight	121.56 g/mol
Synonyms	4-Chlorobutanamide; γ-Chlorobutyramide; NSC 402124; Butanamide, 4-chloro-; ω-Chlorobutyramide; 4-Chloro-butyramide; 4-Chlorobutyric acid amide
EINECS	219-512-8

Quality Control

Our 4-Chlorobutyramide is manufactured under strict quality management protocols. Each batch undergoes comprehensive analytical testing, including HPLC for purity, identity confirmation by FT-IR and NMR, and precise determination of residual solvents and moisture content. A Certificate of Analysis (COA) detailing all specifications is provided with every shipment to ensure traceability and compliance with your internal quality standards and regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); therefore, the container must be kept tightly sealed after each use to prevent degradation from atmospheric moisture. Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Melting Point	88 - 92 °C
Loss on Drying	≤ 1.0%
Heavy Metals (as Pb)	≤ 20 ppm
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.