Description

Amo 1618 is a quaternary ammonium salt widely recognized as a potent and selective inhibitor of protein prenyltransferases, specifically protein farnesyltransferase. This compound is a critical research tool in biochemical and pharmacological studies, enabling the investigation of signal transduction pathways, cell proliferation, and oncogenesis. It is essential for researchers and development teams in the pharmaceutical, biotechnology, and life science sectors.

Application

• Biochemical Research: A key inhibitor for studying protein farnesylation and its role in Ras protein signaling pathways.
• Cancer Research: Used in vitro to investigate the inhibition of tumor cell growth by blocking farnesyltransferase activity.
• Enzymology Studies: Serves as a standard inhibitor for characterizing the kinetics and mechanism of prenyltransferase enzymes.
• Pharmaceutical Development: Employed as a reference compound in high-throughput screening assays for novel anticancer drug discovery.
• Cell Biology: Utilized to study the impact of disrupted protein prenylation on cell cycle progression and membrane localization of proteins.
• Academic Research: A fundamental reagent for universities and research institutes exploring post-translational modifications.

Basic Information

Product Name	Amo 1618
CAS No.	2438-53-1
Molecular Formula	C₂₅H₄₂ClN
Molecular Weight	392.07 g/mol
Synonyms	Farnesyltransferase Inhibitor I; (1,5-Dihydro-1-[(3-methylphenyl)methyl]-4H-1,2,4-triazol-4-ylidene)phenylmethanaminium Chloride; N-[(E)-1,5-Dihydro-1-(3-methylbenzyl)-4H-1,2,4-triazol-4-ylidene]benzenemethanaminium Chloride; 1-Benzyl-3-cinnamylimidazolium Chloride; Amo-1618; Protein Farnesyltransferase Inhibitor I; FTase Inhibitor I
EINECS	Contact for details

Quality Control

Our Amo 1618 is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity verification and identity confirmation by spectroscopic methods, to ensure it meets the high standards required for research applications. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This product is hygroscopic (moisture-sensitive) and must be kept in a desiccated environment to maintain stability and potency.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.