Description

Cyclobutane-1,3-Dicarboxylic Acid CAS NO 2398-16-5 is a versatile alicyclic dicarboxylic acid featuring a strained four-membered ring, making it a valuable building block in synthetic organic chemistry. This compound is particularly significant for its role as a rigid, conformationally restricted linker in the development of novel pharmaceuticals and advanced materials. It is essential for research chemists and process development scientists in the pharmaceutical, agrochemical, and specialty polymer industries who require high-purity intermediates for complex synthesis.

Application

• Pharmaceutical Intermediate: Serves as a key precursor in the synthesis of active pharmaceutical ingredients (APIs), especially those requiring rigid, bicyclic, or spirocyclic structures to modulate biological activity and pharmacokinetic properties.
• Agrochemical Synthesis: Used in the research and development of novel herbicides, fungicides, and insecticides, where the cyclobutane ring can impart unique steric and electronic properties.
• Polymer & Material Science: Acts as a monomer or cross-linking agent for producing specialty polyamides, polyesters, and polyimides with enhanced thermal stability and mechanical strength.
• Ligand & Catalyst Development: Employed in the design of novel chiral ligands and metal-organic frameworks (MOFs) for asymmetric catalysis and separation technologies.
• Academic & Industrial R&D: A fundamental reagent for methodological studies in organic synthesis, including ring-opening, ring-expansion, and photochemical reactions.
• Peptidomimetics & Bioisosteres: The dicarboxylic acid functionality and rigid core are valuable for creating peptide mimics and bioisosteric replacements in medicinal chemistry programs.

Basic Information

Product Name	Cyclobutane-1,3-Dicarboxylic Acid
CAS No.	2398-16-5
Molecular Formula	C6H8O4
Molecular Weight	144.13 g/mol
Synonyms	1,3-Cyclobutanedicarboxylic Acid; Cyclobutane-1,3-dicarboxylic acid; 1,3-CBDA; NSC 51143; 1,3-Cyclobutane dicarboxylic acid; 2398-16-5; Cyclobutane-m-dicarboxylic acid
EINECS	219-254-5

Quality Control

Our Cyclobutane-1,3-Dicarboxylic Acid is manufactured under a strict quality management system. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and titration methods, to ensure high purity and consistent performance. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Due to its hygroscopic nature, store in a cool, dry place at 15-25°C under an inert atmosphere or with appropriate desiccant to prevent moisture absorption. Keep the container tightly sealed when not in use.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals (as Pb)	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.