Description

(Trimethylsilyl)Acetic Acid is a versatile organosilicon compound that serves as a valuable building block in organic synthesis. Its unique structure, featuring a reactive carboxylic acid group adjacent to a silyl-protecting group, makes it a critical reagent for introducing functionalized silyl moieties into target molecules. This compound is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and advanced materials sectors, particularly for applications requiring precise molecular modification and protection strategies.

Application

• Pharmaceutical Intermediates: Key building block in the synthesis of active pharmaceutical ingredients (APIs), especially for silicon-containing drugs or prodrugs.
• Agrochemical Synthesis: Used in the production of novel pesticides and herbicides where the silyl group modifies biological activity and stability.
• Polymer & Material Science: Serves as a monomer or modifier in the creation of specialty silicones, coatings, and advanced polymeric materials with tailored properties.
• Organic Synthesis Reagent: Acts as a versatile reagent for homologation reactions, carbanion stabilization, and as a precursor to other functionalized organosilanes.
• Protecting Group Chemistry: Utilized for the temporary protection of hydroxyl or other functional groups during complex multi-step synthetic sequences.
• Cross-Coupling Reactions: Employed as a substrate in palladium-catalyzed cross-coupling reactions to construct complex molecular architectures.

Basic Information

Product Name	(Trimethylsilyl)Acetic Acid
CAS No.	2345-38-2
Molecular Formula	C5H12O2Si
Molecular Weight	132.23 g/mol
Synonyms	2-(Trimethylsilyl)acetic acid; Acetic acid, 2-(trimethylsilyl)-; (Trimethylsilyl)ethanoic acid; TMS-acetic acid; Trimethylsilylacetic Acid; NSC 163083; (Trimethylsilyl)essigsäure (German)
EINECS	219-058-8

Quality Control

Our (Trimethylsilyl)Acetic Acid is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chromatography (HPLC, GC) and spectroscopic methods (NMR, IR), to ensure high purity and consistency. Certificates of Analysis (COA) detailing all specifications are provided with every shipment to guarantee compliance with your research or production requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to prevent moisture absorption, which can affect product quality and stability.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (GC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.