Description

2-(4-(Trifluoromethyl)Phenyl)Cyclopropanecarboxylic Acid is a high-value, multifunctional organic building block featuring a cyclopropane ring and a trifluoromethylphenyl group. This unique structure makes it a critical intermediate for synthesizing advanced pharmaceuticals and agrochemicals, where the cyclopropane moiety and fluorine atoms impart desirable biological activity and metabolic stability. It is primarily sought after by R&D chemists and process development teams in the pharmaceutical, agrochemical, and specialty chemical industries for creating novel active ingredients and fine chemicals.

Application

• Pharmaceutical Intermediate: A key synthon in the research and production of active pharmaceutical ingredients (APIs), particularly for candidates targeting central nervous system (CNS) disorders, anti-inflammatory agents, and antiviral drugs.
• Agrochemical Synthesis: Used in the development of advanced herbicides, fungicides, and insecticides, where the trifluoromethyl group enhances lipophilicity and bioactivity.
• Ligand and Catalyst Preparation: Serves as a precursor for chiral ligands and organocatalysts used in asymmetric synthesis, leveraging the steric constraint of the cyclopropane ring.
• Material Science Research: Employed in the synthesis of monomers and polymers with specific optical or electronic properties for advanced material applications.
• Fluorine Chemistry Building Block: Essential for introducing the trifluoromethylphenyl motif into complex molecules in medicinal and synthetic chemistry research.
• Custom Synthesis and Contract Manufacturing: A vital starting material for custom synthesis projects and scale-up processes in fine chemical production.

Basic Information

Product Name	2-(4-(Trifluoromethyl)Phenyl)Cyclopropanecarboxylic Acid
CAS No.	2262-03-5
Molecular Formula	C11H9F3O2
Molecular Weight	230.18 g/mol
Synonyms	2-[4-(Trifluoromethyl)phenyl]cyclopropanecarboxylic acid; α-(4-Trifluoromethylphenyl)cyclopropanecarboxylic Acid; 2-(4-Trifluoromethylphenyl)cyclopropanecarboxylic Acid; 2-(p-Trifluoromethylphenyl)cyclopropanecarboxylic Acid; Cyclopropanecarboxylic acid, 2-[4-(trifluoromethyl)phenyl]-; 4-(Trifluoromethyl)benzenepropanoic acid, alpha,β-cyclopropano-; 2262-03-5
EINECS	Contact for details

Quality Control

Our 2-(4-(Trifluoromethyl)Phenyl)Cyclopropanecarboxylic Acid is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specified parameters. Our quality commitment supports compliance with cGMP, ISO, and other relevant regulatory frameworks for pharmaceutical and industrial applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to minimize exposure to atmospheric moisture. Store away from incompatible materials such as strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Related Substances (HPLC)	Total impurities ≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.