Description

3,3,6,6-Tetramethyl-1,4-Cyclohexadiene is a specialized, highly substituted cyclic diene of significant interest in advanced organic synthesis. Its unique sterically hindered structure makes it a valuable building block for creating complex molecular architectures and functional materials. This compound is primarily sought after by research chemists and process development scientists in the pharmaceutical, agrochemical, and specialty polymer industries for applications requiring precise molecular control.

Application

• Pharmaceutical Intermediate: Serves as a key precursor in the synthesis of sterically demanding, bioactive molecules and complex natural product analogs.
• Agrochemical Synthesis: Used in the development of novel pesticides and herbicides where its unique carbon skeleton contributes to specific biological activity.
• Ligand and Catalyst Development: Acts as a starting material for synthesizing specialized ligands used in asymmetric catalysis and organometallic chemistry.
• Material Science Research: Employed in the creation of novel organic frameworks, polymers, and advanced materials with tailored properties.
• Fine Chemical Production: Utilized as a high-value intermediate in custom synthesis and contract manufacturing for specialty chemicals.
• Academic & Industrial R&D: A critical reagent for methodological studies in organic synthesis, including Diels-Alder reactions and other cycloadditions.

Basic Information

Product Name	3,3,6,6-Tetramethyl-1,4-Cyclohexadiene
CAS No.	2223-54-3
Molecular Formula	C10H16
Molecular Weight	136.23 g/mol
Synonyms	1,4-Cyclohexadiene, 3,3,6,6-tetramethyl-; Tetramethyl-1,4-cyclohexadiene; 3,3,6,6-Tetramethylcyclohexa-1,4-diene; TMCHD; 1,4-Dihydro-3,3,6,6-tetramethylbenzene (tautomer); 3,3,6,6-Tetramethyl-1,4-cyclohexadiene; 2223-54-3 (CAS)
EINECS	218-746-4

Quality Control

We maintain stringent quality control protocols for all our chemical intermediates. Each batch of 3,3,6,6-Tetramethyl-1,4-Cyclohexadiene is analyzed using advanced chromatographic and spectroscopic techniques to ensure identity, purity, and consistency. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Due to its highly volatile and easily oxidized nature, this product should be stored under an inert atmosphere (e.g., nitrogen or argon) in a cool, dry, and well-ventilated area. Recommended long-term storage temperature is 2-8°C. Allow the container to reach room temperature before opening to minimize moisture ingress and degradation.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (GC)	≥ 97.0%
Purity (HPLC)	≥ 96.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.