Description

3,4,5,6-Tetrahydro-2H-Azepin-7-Amine is a versatile seven-membered nitrogen heterocycle, specifically a cyclic amine, that serves as a critical building block in advanced organic synthesis. Its value lies in its unique azepine scaffold, which is a privileged structure in medicinal chemistry for constructing pharmacologically active molecules. This intermediate is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries developing novel active ingredients, as well as in academic settings for exploring new chemical space.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of central nervous system (CNS) active compounds, potential enzyme inhibitors, and novel drug candidates featuring the azepine ring system.
• Agrochemical Synthesis: Used in the research and development of new herbicides, fungicides, and insecticides where the saturated azepine core imparts specific biological activity.
• Ligand and Catalyst Development: Serves as a starting material for creating novel chelating ligands and organocatalysts used in asymmetric synthesis and metal complexation.
• Polymer Chemistry: Can be incorporated as a monomer or cross-linking agent to modify the properties of specialty polymers, such as polyamides or resins.
• Chemical Research & Development: A valuable scaffold for medicinal chemistry programs, fragment-based drug discovery, and the exploration of structure-activity relationships (SAR).
• Fine Chemical Production: Employed in the multi-step synthesis of complex, high-value specialty chemicals for various industrial applications.

Basic Information

Product Name	3,4,5,6-Tetrahydro-2H-Azepin-7-Amine
CAS No.	2214-67-7
Molecular Formula	C6H12N2
Molecular Weight	112.17 g/mol
Synonyms	7-Amino-2H-azepine, hexahydro-; 7-Aminohexahydroazepine; 2H-Azepin-7-amine, 3,4,5,6-tetrahydro-; Hexahydro-2H-azepin-7-amine; 1-Aza-2-cycloheptene-7-amine, perhydro-; 7-Aminoazepane; Cycloheptaimine; Perhydroazepin-7-amine
EINECS	218-690-5

Quality Control

Our 3,4,5,6-Tetrahydro-2H-Azepin-7-Amine is produced under strict quality management protocols. Each batch undergoes comprehensive analytical testing, including chromatographic purity analysis and identity confirmation, to ensure it meets the high standards required for research and industrial synthesis. A Certificate of Analysis (COA) detailing specific results for purity, assay, and impurity profiles is provided with every shipment to guarantee traceability and consistency.

Storage

Preserve in a tightly closed container, protected from light. Due to its hygroscopic and easily oxidized nature, this material should be stored under an inert atmosphere (e.g., nitrogen or argon) in a cool, dry place. Recommended long-term storage temperature is 2-8°C. Allow the sealed container to reach ambient temperature before opening to minimize moisture ingress.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC/HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.