Description

Nα-Tosyl-L-Lysine is a protected derivative of the essential amino acid L-lysine, featuring a tosyl group on the α-amino function. This modification is critical for its primary role as a key synthetic intermediate and building block in peptide chemistry and pharmaceutical research. It is essential for researchers and manufacturers in the pharmaceutical, biotechnology, and fine chemical sectors who require high-purity, protected amino acids for the synthesis of complex peptides, peptide mimetics, and active pharmaceutical ingredients (APIs).

Application

• Peptide Synthesis: A fundamental building block (Fmoc or Boc strategy) for introducing protected lysine residues into peptide chains during solid-phase or solution-phase synthesis.
• Pharmaceutical Intermediate: Serves as a critical precursor in the research and development of novel therapeutic peptides and protein-based drugs.
• Bioconjugation & Labeling: The tosyl-protected amine can be used in specific chemical strategies for attaching labels, probes, or other molecules to peptides or proteins.
• Biochemical Research: Used in enzymatic studies and as a substrate or inhibitor analog in research targeting lysine-specific biological processes.
• Fine Chemical Synthesis: Employed as a chiral synthon for the asymmetric synthesis of more complex organic molecules and natural product analogs.

Basic Information

Product Name	Nα-Tosyl-L-Lysine
CAS No.	2104-87-2
Molecular Formula	C13H20N2O4S
Molecular Weight	300.37 g/mol
Synonyms	Tosyl-L-lysine; N-Tosyl-L-lysine; N(alpha)-Tosyl-L-lysine; L-Lysine, N-[(4-methylphenyl)sulfonyl]-; (S)-2-Amino-6-aminohexanoic acid N-tosyl derivative; p-Toluenesulfonyl-L-lysine; Tos-Lys-OH; TLC
EINECS	218-267-0

Quality Control

Our Nα-Tosyl-L-Lysine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing to ensure identity, purity, and consistency. We provide Certificates of Analysis (COA) with key parameters including assay (HPLC), optical rotation, and residual solvent levels, meeting the stringent requirements of research and cGMP-guided synthesis. Specifications can be aligned with customer-specific pharmacopeial or internal standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The product is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Optical Rotation [α]	Specific range provided on COA
Loss on Drying	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.