Description

2,3,4,5,6-Pentafluorophenyl 4-Methylbenzenesulfonate is a high-purity, specialized chemical intermediate featuring a perfluorinated phenyl group activated by a tosylate leaving group. This compound is critically important for its role in facilitating efficient nucleophilic aromatic substitution reactions under mild conditions, enabling the precise introduction of the pentafluorophenyl moiety into complex molecular architectures. It is primarily sought after by research chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials sectors for synthesizing novel fluorinated compounds, ligands, and functional polymers.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of fluorinated active pharmaceutical ingredients (APIs) and diagnostic agents, leveraging the enhanced metabolic stability and lipophilicity imparted by the pentafluorophenyl group.
• Agrochemical Synthesis: Used in creating novel fluorinated pesticides and herbicides, where the introduction of fluorine atoms can significantly improve biological activity and environmental persistence.
• Ligand and Catalyst Preparation: Serves as a precursor for synthesizing specialized fluorinated ligands used in catalysis, particularly in cross-coupling and polymerization reactions.
• Advanced Material Development: Employed in the production of fluorinated polymers, liquid crystals, and organic electronic materials to modify surface properties, dielectric constants, and thermal stability.
• Proteomics and Bioconjugation: Utilized in chemical biology for labeling and modifying biomolecules, taking advantage of the high reactivity of the tosylate group for selective conjugation.
• Organic Synthesis Research: A versatile reagent in academic and industrial R&D for exploring new synthetic methodologies involving perfluoroaromatic compounds.

Basic Information

Product Name	2,3,4,5,6-Pentafluorophenyl 4-Methylbenzenesulfonate
CAS No.	2069-36-5
Molecular Formula	C13H7F5O3S
Molecular Weight	338.25 g/mol
Synonyms	Pentafluorophenyl Tosylate; 4-Methylbenzenesulfonic Acid 2,3,4,5,6-Pentafluorophenyl Ester; PFP-Tosylate; Tosyl Pentafluorophenyl Ester; 2,3,4,5,6-Pentafluorophenyl Tosylate; Pentafluorophenyl p-Toluenesulfonate; 4-Methylbenzenesulfonyl Pentafluorobenzene; PFP-OTs
EINECS	Contact for details

Quality Control

Our production of 2,3,4,5,6-Pentafluorophenyl 4-Methylbenzenesulfonate adheres to stringent quality management protocols. Every batch undergoes comprehensive analytical characterization, including HPLC, NMR, and GC-MS, to ensure high chemical purity and identity confirmation. Certificates of Analysis (COA) detailing lot-specific results are provided to guarantee traceability and compliance with your research or production standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). The compound is moisture-sensitive; keep the container tightly sealed under an inert atmosphere such as nitrogen or argon for long-term storage to maintain optimal purity and reactivity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.