Description

3-Butyn-2-ol is a versatile terminal alkyne alcohol, a key building block in organic synthesis. Its unique structure, featuring both a hydroxyl group and a reactive acetylene moiety, makes it an essential intermediate for constructing complex molecular frameworks. This compound is primarily utilized by research institutions and industrial manufacturers in the pharmaceutical, agrochemical, and specialty chemical sectors for applications such as click chemistry, Sonogashira couplings, and the synthesis of chiral ligands.

Application

• Pharmaceutical Intermediate: A crucial precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for drugs targeting central nervous system disorders.
• Agrochemical Synthesis: Used in the production of advanced fungicides, herbicides, and plant growth regulators.
• Click Chemistry Reagent: Serves as a fundamental component in Huisgen cycloaddition reactions for bioconjugation and material science applications.
• Chiral Ligand & Catalyst Preparation: Employed in the manufacture of chiral auxiliaries and catalysts for asymmetric synthesis.
• Polymer & Material Science: Acts as a monomer or cross-linking agent for creating specialty polymers with tailored properties.
• Organic Synthesis Building Block: Used in Sonogashira, Glaser, and other palladium-catalyzed coupling reactions to introduce acetylene functionality.

Basic Information

Product Name	3-Butyn-2-ol
CAS No.	2028-63-9
Molecular Formula	C₄H₆O
Molecular Weight	70.09 g/mol
Synonyms	3-Butyn-2-ol; 2-Butyn-4-ol; 1-Methyl-2-propyn-1-ol; 2-Propyn-1-ol, 1-methyl-; But-3-yn-2-ol; Methyl propargyl carbinol; 3-Butyn-2-ol (8CI,9CI); 1-Methyl-2-propyn-1-ol; NSC 66417
EINECS	217-970-5

Quality Control

Our 3-Butyn-2-ol is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including GC, HPLC, and NMR, to ensure high purity and consistency. A comprehensive Certificate of Analysis (COA) detailing identity, assay, and impurity profiles is provided with each shipment. We adhere to cGMP principles where applicable to support our customers in regulated industries.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, well-ventilated place away from heat, sparks, and open flame. Due to its highly volatile nature, keep container tightly sealed when not in use. Recommended storage temperature is 2-8°C for long-term stability. Keep away from strong oxidizing agents and acids.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (GC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Specific Gravity (20°C)	0.905 - 0.925
Refractive Index (20°C)	1.420 - 1.430

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.