Description

12-Crown-4 is a crucial member of the crown ether family, specifically designed as a selective chelating agent for lithium ions. This compound is essential for applications requiring the stabilization, solubilization, or transport of lithium cations in non-aqueous systems. It is a fundamental building block in advanced materials science, battery research, and organic synthesis. Industries such as pharmaceuticals, specialty chemicals, and energy storage rely on its unique ion-binding properties.

Application

• Lithium-Ion Battery Electrolyte Additive: Used to improve lithium-ion transport and stabilize the solid-electrolyte interphase (SEI) layer in advanced battery formulations.
• Phase-Transfer Catalyst (PTC): Facilitates reactions between ionic reagents in organic solvents, enhancing reaction rates and yields in organic synthesis.
• Lithium Salt Solubilizer: Increases the solubility and conductivity of lithium salts in aprotic organic solvents for electrochemical applications.
• Chemical Sensor Development: Serves as a key recognition element in ion-selective electrodes and optical sensors for lithium detection.
• Polymer Electrolytes: Incorporated into polymer matrices to create solid or gel electrolytes with enhanced ionic conductivity for solid-state batteries.
• Organometallic Chemistry: Used to prepare and stabilize lithium organometallic complexes for use in stoichiometric and catalytic reactions.
• Analytical Chemistry: Employed in separation science and chromatography as a mobile phase modifier for ion-pair chromatography.
• Fundamental Research: A standard reagent for studying cation complexation, host-guest chemistry, and supramolecular assembly processes.

Basic Information

Product Name	12-Crown-4
CAS No.	294-93-9
Molecular Formula	C8H16O4
Molecular Weight	176.21 g/mol
Synonyms	1,4,7,10-Tetraoxacyclododecane; 12-Crown-4 ether; 1,4,7,10-Tetraoxacyclododecane, 12-Crown-4; Lithium Ionophore I; 12-C-4; Cyclic Tetraethylene Glycol; 12-Crown-4, 98+%; 4,7,10,13-Tetraoxa-1-azacyclopentadecane (related structure)
EINECS	206-045-8

Quality Control

Our 12-Crown-4 is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including assay by GC or HPLC, to ensure high purity and consistent performance. Certificates of Analysis (COA) detailing purity, identity, and key physical parameters are provided with every shipment. We support compliance with relevant industry standards for research and development applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under dry conditions to prevent degradation. Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (GC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Refractive Index (n20/D)	1.450 - 1.455
Density (g/mL, 20°C)	1.090 - 1.110

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.