Description

Methyl 3-Amino-3-Cyclobutylpropanoate Hydrochloride is a high-purity, pharmaceutically relevant building block and intermediate. This compound is valued for its unique cyclobutyl scaffold, which is increasingly important in modern medicinal chemistry for creating novel bioactive molecules with improved metabolic stability and potency. It is primarily sought by research institutions and pharmaceutical companies engaged in the development of new therapeutic agents, particularly for central nervous system (CNS) and antiviral applications.

Application

• Pharmaceutical Intermediate: A key chiral building block for the synthesis of novel active pharmaceutical ingredients (APIs).
• Medicinal Chemistry Research: Used in hit-to-lead and lead optimization campaigns to explore structure-activity relationships (SAR).
• Protease Inhibitor Development: Serves as a precursor for compounds targeting viral proteases or other enzyme families.
• Peptidomimetic Synthesis: The ester and amino acid-like structure makes it suitable for creating peptide analogs.
• Chemical Biology Probes: Utilized in the development of tool compounds for target identification and validation.
• Process Chemistry & Scale-Up: Supplied for route scouting and optimization towards commercial-scale API manufacturing.

Basic Information

Product Name	Methyl 3-Amino-3-Cyclobutylpropanoate Hydrochloride
CAS No.	1984078-68-3
Molecular Formula	C9H18ClNO2
Molecular Weight	207.70 g/mol
Synonyms	3-Amino-3-cyclobutylpropanoic acid methyl ester hydrochloride; Methyl 3-amino-3-cyclobutylpropionate HCl; 3-Cyclobutyl-β-alanine methyl ester hydrochloride; Methyl β-amino-β-cyclobutylpropionate hydrochloride; (3-Amino-3-cyclobutyl-propionic acid methyl ester) hydrochloride; 1984078-68-3; Methyl 3-cyclobutyl-3-aminopropanoate hydrochloride
EINECS	Contact for details

Quality Control

Our Methyl 3-Amino-3-Cyclobutylpropanoate Hydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis, and identity confirmation (IR, NMR) to ensure it meets the stringent requirements for pharmaceutical R&D and process chemistry. A detailed Certificate of Analysis (COA) is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under dry conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.