Description

Methyl 3-Aminocubane-1-Carboxylate Hydrochloride is a high-value, synthetically challenging pharmaceutical intermediate derived from the unique cubane scaffold. This compound matters for its role in advancing novel drug discovery, particularly in medicinal chemistry programs targeting central nervous system (CNS) disorders and other therapeutic areas where the rigid, three-dimensional cubane structure is used to modulate biological activity and improve metabolic stability. Researchers and process chemists in pharmaceutical R&D and fine chemical synthesis need this building block to develop new active pharmaceutical ingredients (APIs) with potentially superior profiles.

Application

• Pharmaceutical Intermediate: A key building block for the synthesis of novel drug candidates, especially in central nervous system (CNS) and antiviral research.
• Medicinal Chemistry Research: Utilized in structure-activity relationship (SAR) studies to explore the bioisosteric potential of the cubane moiety.
• Advanced Material Science: Serves as a precursor for high-energy-density materials (HEDMs) and specialty polymers due to the strained cubane cage.
• Academic & Industrial R&D: Used in methodological development and synthetic chemistry research focused on strained hydrocarbon systems.
• Proteolysis Targeting Chimera (PROTAC) Development: Potential use as a specialized linker or component in bifunctional molecule design.
• Peptidomimetics: Incorporation into peptide analogs to confer rigidity and alter conformational properties.

Basic Information

Product Name	Methyl 3-Aminocubane-1-Carboxylate Hydrochloride
CAS No.	1980050-27-8
Molecular Formula	C11H15NO2·HCl
Molecular Weight	229.70 g/mol (Free base: 193.24 g/mol)
Synonyms	Methyl 3-aminopentacyclo[4.2.0.02,5.03,8.04,7]octane-1-carboxylate hydrochloride; 3-Aminocubane-1-carboxylic acid methyl ester hydrochloride; Cubane-1-carboxylic acid, 3-amino-, methyl ester, hydrochloride; Methyl 3-aminocubane-1-carboxylate HCl; 1-Methoxycarbonyl-3-aminocubane hydrochloride
EINECS	Contact for details

Quality Control

Our Methyl 3-Aminocubane-1-Carboxylate Hydrochloride is produced under strict quality management protocols. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation by NMR and MS, to ensure compliance with research-grade specifications. Certificates of Analysis (COA) detailing batch-specific results are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to minimize exposure to atmospheric moisture. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.