Description

6-Iodo-Imidazo[1,2-B]Pyridazine Hydrochloride is a high-purity, advanced pharmaceutical intermediate and building block for medicinal chemistry research. This compound is critical for the synthesis of novel drug candidates, particularly in the development of kinase inhibitors and other targeted therapies. It is primarily utilized by pharmaceutical R&D departments, biotechnology companies, and contract research organizations (CROs) focused on oncology and inflammatory disease research.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel small-molecule drug candidates, especially for targeted cancer therapies.
• Kinase Inhibitor Development: Used in the research and development of potent and selective kinase inhibitors due to its imidazopyridazine core structure.
• Medicinal Chemistry Research: Serves as a versatile scaffold for structure-activity relationship (SAR) studies and lead optimization in drug discovery programs.
• Bioconjugation & Probe Synthesis: The iodine moiety allows for further functionalization via cross-coupling reactions, useful for creating labeled probes or antibody-drug conjugates (ADCs).
• Contract Research & Manufacturing (CRO/CMO): Supplied to organizations providing custom synthesis and process development services for the pharmaceutical industry.
• Academic Research: Used in university and institutional labs for fundamental research in heterocyclic chemistry and bioorganic chemistry.

Basic Information

Product Name	6-Iodo-Imidazo[1,2-B]Pyridazine Hydrochloride
CAS No.	1951439-01-2
Molecular Formula	C7H5IN3·HCl
Molecular Weight	309.50 g/mol
Synonyms	6-Iodoimidazo[1,2-b]pyridazine hydrochloride; Imidazo[1,2-b]pyridazine, 6-iodo-, hydrochloride (1:1); 6-Iodo-1H-imidazo[1,2-b]pyridazine hydrochloride; 6-Iodoimidazopyridazine HCl; 1951439-01-2; 6-Iodo-imidazo[1,2-b]pyridazine HCl salt
EINECS	Contact for details

Quality Control

Our 6-Iodo-Imidazo[1,2-B]Pyridazine Hydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and KF titration for moisture content, to ensure it meets the stringent requirements for pharmaceutical R&D. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming identity, purity, and conformance to agreed specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and light-sensitive; therefore, containers must be kept sealed under an inert atmosphere (e.g., nitrogen or argon) when not in use to prevent degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	Off-white to light yellow solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.