Description

tert-Butyl ((3R,4S)-3-Hydroxytetrahydro-2H-Pyran-4-Yl)Carbamate is a high-purity chiral building block and advanced pharmaceutical intermediate of significant synthetic value. Its defined stereochemistry and protected functional groups make it a critical component for constructing complex molecular architectures in medicinal chemistry. This compound is primarily utilized by research institutions and pharmaceutical manufacturers engaged in the development of novel active pharmaceutical ingredients (APIs), particularly for antiviral and oncology therapeutics.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the multi-step synthesis of complex drug candidates, especially protease inhibitors and other small molecule therapeutics.
• Antiviral Drug Development: Serves as a crucial building block in the research and production of antiviral agents, leveraging its pyran-based scaffold.
• Oncology Research: Used in the construction of targeted cancer therapy molecules due to its ability to introduce specific stereocenters.
• Peptidomimetics: Employed in the design and synthesis of peptide mimics, where the carbamate and hydroxyl groups are essential for bioactivity and stability.
• Asymmetric Synthesis: Acts as a starting material or intermediate in catalytic asymmetric reactions to produce enantiomerically pure compounds.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects requiring high stereochemical fidelity.

Basic Information

Product Name	tert-Butyl ((3R,4S)-3-Hydroxytetrahydro-2H-Pyran-4-Yl)Carbamate
CAS No.	1932435-72-7
Molecular Formula	C10H19NO4
Molecular Weight	217.26 g/mol
Synonyms	(3R,4S)-4-[(tert-Butoxycarbonyl)amino]tetrahydro-2H-pyran-3-ol; tert-Butyl N-[(3R,4S)-3-hydroxytetrahydro-2H-pyran-4-yl]carbamate; Boc-4-amino-3-hydroxytetrahydropyran ((3R,4S)-isomer); (3R,4S)-3-Hydroxy-4-(Boc-amino)tetrahydropyran; Boc-AHP-OH ((3R,4S)-form); 4-N-Boc-amino-3-hydroxytetrahydropyran (stereospecific); Carbamic acid, N-[(3R,4S)-3-hydroxy-4-tetrahydro-2H-pyranyl]-, 1,1-dimethylethyl ester
EINECS	Contact for details

Quality Control

Our tert-Butyl ((3R,4S)-3-Hydroxytetrahydro-2H-Pyran-4-Yl)Carbamate is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral HPLC to confirm stereochemical purity and identity. We provide Certificates of Analysis (COA) with detailed specifications for purity, enantiomeric excess, and impurity profiles, ensuring compliance with research and cGMP-grade standards for pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.