Description

tert-Butyl (Cis)-6-(Hydroxymethyl)-Tetrahydro-2H-Pyran-3-Ylcarbamate is a high-purity, advanced pharmaceutical intermediate characterized by its specific stereochemistry and functional groups. This compound matters as a critical building block in the synthesis of complex active pharmaceutical ingredients (APIs), where its defined cis-configuration and protected amine functionality are essential for precise molecular construction. It is primarily needed by research institutions and manufacturers in the pharmaceutical and fine chemical industries engaged in developing new therapeutic agents, particularly in areas like antiviral or oncology research.

Application

• Pharmaceutical Intermediate: Serves as a key chiral synthon in the multi-step synthesis of novel drug candidates and active pharmaceutical ingredients (APIs).
• Protease Inhibitor Research: Used in the development and scale-up of protease inhibitor compounds, a crucial class for antiviral therapies.
• Peptidomimetic Chemistry: Acts as a constrained scaffold or building block for designing peptide-like molecules with enhanced metabolic stability.
• Medicinal Chemistry R&D: Employed in lead optimization and structure-activity relationship (SAR) studies to explore new chemical entities.
• Asymmetric Synthesis: Utilized as a starting material or intermediate in stereoselective synthesis due to its defined cis-stereochemistry.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects under cGMP guidelines.

Basic Information

Product Name	tert-Butyl (Cis)-6-(Hydroxymethyl)-Tetrahydro-2H-Pyran-3-Ylcarbamate
CAS No.	1923238-60-1
Molecular Formula	C11H21NO4
Molecular Weight	231.29 g/mol
Synonyms	tert-Butyl N-[(3S,6R)-6-(hydroxymethyl)oxan-3-yl]carbamate; (3S,6R)-6-(Hydroxymethyl)-N-Boc-tetrahydropyran-3-amine; tert-Butyl ((3S,6R)-6-(hydroxymethyl)tetrahydro-2H-pyran-3-yl)carbamate; (Cis)-6-(Hydroxymethyl)-Tetrahydro-2H-Pyran-3-Ylcarbamic Acid tert-Butyl Ester; Boc-Cis-THP-amine Alcohol; (3S,6R)-3-((tert-Butoxycarbonyl)amino)tetrahydro-2H-pyran-6-methanol; BOC-Cis-THP-Amine-CH2OH
EINECS	Contact for details

Quality Control

Our tert-Butyl (Cis)-6-(Hydroxymethyl)-Tetrahydro-2H-Pyran-3-Ylcarbamate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral HPLC for stereochemical purity and identity confirmation, to ensure compliance with stringent industry standards. Certificates of Analysis (COA) detailing purity, assay, and impurity profiles are provided with every shipment to guarantee traceability and batch-to-batch consistency for your critical R&D and cGMP manufacturing processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive); ensure the container is sealed under an inert atmosphere after each use to maintain stability and prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% de (cis-isomer)
Assay	97.0% - 102.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.