Description

4-(Aminomethyl)Tetrahydro-2H-Pyran-4-Carbonitrile Hydrochloride is a high-purity, advanced pharmaceutical intermediate featuring a unique cyclic ether and nitrile functional group. This compound is critical for the synthesis of complex bioactive molecules, offering a versatile scaffold for medicinal chemistry and drug discovery. It is primarily sought after by research institutions and pharmaceutical manufacturers developing novel therapeutic agents, particularly in the areas of central nervous system (CNS) and metabolic disease treatments.

Application

• Pharmaceutical Intermediate: Serves as a key building block in the synthesis of novel active pharmaceutical ingredients (APIs) and drug candidates.
• Medicinal Chemistry Research: Used as a versatile scaffold for structure-activity relationship (SAR) studies and lead optimization in drug discovery programs.
• Protease Inhibitor Development: The aminomethyl and nitrile moieties make it a valuable precursor for compounds targeting various protease enzymes.
• Chemical Biology Probes: Utilized in the development of molecular probes for studying biological pathways and target engagement.
• Agrochemical Synthesis: Acts as an intermediate in the research and development of new crop protection agents and herbicides.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects requiring high-purity, complex intermediates.

Basic Information

Product Name	4-(Aminomethyl)Tetrahydro-2H-Pyran-4-Carbonitrile Hydrochloride
CAS No.	1909325-40-1
Molecular Formula	C8H15ClN2O
Molecular Weight	190.67 g/mol
Synonyms	4-(Aminomethyl)tetrahydro-2H-pyran-4-carbonitrile hydrochloride; 4-(Aminomethyl)tetrahydropyran-4-carbonitrile HCl; 4-(Aminomethyl)oxane-4-carbonitrile hydrochloride; THP-Aminomethyl-Carbonitrile HCl; 4-Cyano-4-(aminomethyl)tetrahydropyran hydrochloride; 4-(Aminomethyl)-4-cyanotetrahydropyran hydrochloride; 4-(Aminomethyl)-4-cyanooxane hydrochloride
EINECS	Contact for details

Quality Control

Every batch of 4-(Aminomethyl)Tetrahydro-2H-Pyran-4-Carbonitrile Hydrochloride is manufactured under strict quality management systems. Our products undergo rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing all specifications are provided with each shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.