Description

1-(3,5-Bis(Trifluoromethyl)Benzyl)-3-((1R,2R)-2-(Dimethylamino)Cyclohexyl)Thiourea is a high-purity, chiral thiourea derivative of significant interest in advanced organic synthesis and pharmaceutical research. This compound matters as a sophisticated building block or potential catalyst/intermediate for the development of novel active pharmaceutical ingredients (APIs) and fine chemicals. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries working on fluorinated molecules and stereoselective transformations.

Application

• Pharmaceutical Intermediate: Serves as a key chiral scaffold or precursor in the synthesis of novel drug candidates, particularly those targeting central nervous system (CNS) disorders or requiring fluorinated motifs for enhanced metabolic stability and bioavailability.
• Asymmetric Organocatalysis: Acts as a potential hydrogen-bond donor catalyst in enantioselective synthetic reactions, leveraging the thiourea moiety and chiral diamine backbone for stereocontrol.
• Agrochemical Research: Used in the discovery and development of new generation pesticides and herbicides, where the trifluoromethyl groups and specific stereochemistry can impart unique biological activity.
• Ligand for Metal Complexes: Functions as a chelating agent or ligand in coordination chemistry for creating metal-organic catalysts used in cross-coupling or other transition metal-catalyzed reactions.
• Chemical Biology Probe: Employed in academic and industrial research to study enzyme inhibition or modulate protein-protein interactions due to its ability to form specific hydrogen bonds.
• Material Science Research: Investigated as a monomer or additive for creating specialty polymers with unique surface properties or fluorine-containing advanced materials.

Basic Information

Item	Details
Product Name	1-(3,5-Bis(Trifluoromethyl)Benzyl)-3-((1R,2R)-2-(Dimethylamino)Cyclohexyl)Thiourea
CAS No.	1908529-26-9
Molecular Formula	C19H23F6N3S
Molecular Weight	455.46 g/mol
Synonyms	(1R,2R)-N1-[3,5-Bis(trifluoromethyl)benzyl]-N2-(dimethylamino)cyclohexane-1,2-diamine carbothioamide; (1R,2R)-2-(Dimethylamino)-N-[[3,5-bis(trifluoromethyl)phenyl]methyl]cyclohexanecarbothioamide; (1R,2R)-1-[[[3,5-Bis(trifluoromethyl)phenyl]methyl]carbamothioyl]-N,N-dimethylcyclohexane-2-amine; Chiral Bis(trifluoromethyl)benzyl Thiourea Derivative; (R,R)-DMACH Thiourea TFA Derivative
EINECS	Contact for details

Quality Control

Our 1-(3,5-Bis(Trifluoromethyl)Benzyl)-3-((1R,2R)-2-(Dimethylamino)Cyclohexyl)Thiourea is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure identity, purity, and chiral integrity, meeting the high standards required for research and development. Certificates of Analysis (COA) providing detailed results from HPLC, NMR, and chiral analysis are available upon request to support your regulatory and quality assurance needs.

Storage

Preserve in a tightly closed container, protected from light. Store at 2-8°C in a cool, dry, and well-ventilated place. This compound is moisture-sensitive; keep the container tightly sealed under an inert atmosphere if necessary. Keep away from strong oxidizers.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.