Description

(Trans)-Tetrahydrofuran-3,4-Dicarboxylic Acid is a high-purity, functionalized tetrahydrofuran derivative serving as a versatile chiral building block and synthetic intermediate. This compound is critical for the development of novel pharmaceuticals and advanced materials due to its rigid, oxygen-containing heterocyclic structure and two carboxylic acid handles for further derivatization. It is primarily sought by research chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for applications in asymmetric synthesis and medicinal chemistry.

Application

• Pharmaceutical Intermediate: Key chiral precursor for the synthesis of active pharmaceutical ingredients (APIs), particularly those targeting central nervous system (CNS) disorders and anti-inflammatory agents.
• Ligand and Catalyst Synthesis: Used to construct sophisticated chiral ligands and organocatalysts for asymmetric catalysis, enhancing enantioselectivity in critical bond-forming reactions.
• Polymer Chemistry: Serves as a monomer or cross-linking agent for producing functionalized polymers and biodegradable materials with tailored properties.
• Agrochemical Research: Intermediate in the development of new herbicides, fungicides, and plant growth regulators with improved efficacy and environmental profiles.
• Chemical Biology Probes: Building block for creating molecular probes and tools to study biological processes and enzyme mechanisms.
• Academic & Contract Research: Essential reagent for methodological development and exploratory synthesis in university and CRO (Contract Research Organization) laboratories.

Basic Information

Item	Details
Product Name	(Trans)-Tetrahydrofuran-3,4-Dicarboxylic Acid
CAS No.	1903836-65-6
Molecular Formula	C6H8O5
Molecular Weight	160.12 g/mol
Synonyms	3,4-Dicarboxytetrahydrofuran; (3R,4S)-Tetrahydrofuran-3,4-dicarboxylic Acid; (3S,4R)-Tetrahydrofuran-3,4-dicarboxylic Acid; THF-3,4-dicarboxylic acid; trans-3,4-Tetrahydrofuran-dicarboxylic Acid; 3,4-Furandicarboxylic acid, tetrahydro-; (3R,4S)-3,4-Dihydroxytetrahydrofuran-2,5-dione (tautomer)
EINECS	Contact for details

Quality Control

Every batch of (Trans)-Tetrahydrofuran-3,4-Dicarboxylic Acid is manufactured under a strict quality management system. We provide comprehensive analytical data to ensure the product meets the high standards required for research and development. Certificates of Analysis (COA) detailing purity, enantiomeric excess (where applicable), and impurity profiles by HPLC, NMR, and chiral analysis are available upon request. Our quality commitment supports compliance with cGMP and ICH guidelines for advanced intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); therefore, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from strong acids and organic solvents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Enantiomeric Excess (Chiral HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.