Description

3-Methanesulfonylbicyclo[1.1.1]pentane-1-carboxylic acid is a high-value, synthetically versatile bicyclic building block. This compound is significant for its unique, highly strained [1.1.1]propellane-derived scaffold, which serves as a bioisostere for para-substituted benzene rings and tert-butyl groups in medicinal chemistry. It is primarily needed by pharmaceutical R&D and agrochemical innovators for the design and synthesis of novel active ingredients, enabling the exploration of new chemical space and the optimization of drug-like properties.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of small molecule drug candidates targeting a range of therapeutic areas.
• Medicinal Chemistry: Used as a saturated bioisostere to replace aromatic rings or tert-butyl groups, improving metabolic stability, solubility, and reducing lipophilicity.
• Agrochemical Research: Intermediate in the development of novel herbicides, fungicides, and insecticides with potentially enhanced efficacy and environmental profiles.
• Chemical Biology: Probe and tool compound synthesis for studying biological pathways and protein-ligand interactions.
• Material Science: Potential monomer or cross-linker for creating polymers with unique mechanical properties derived from the strained bicyclic core.
• Custom Synthesis & Contract Manufacturing: Sourced by CROs and CDMOs for client projects requiring advanced, specialized chemical intermediates.

Basic Information

Product Name	3-Methanesulfonylbicyclo[1.1.1]pentane-1-carboxylic Acid
CAS No.	1886967-73-2
Molecular Formula	C8H12O4S
Molecular Weight	204.24 g/mol
Synonyms	3-(Methylsulfonyl)bicyclo[1.1.1]pentane-1-carboxylic acid; Bicyclo[1.1.1]pentane-1-carboxylic acid, 3-(methylsulfonyl)-; 3-Methanesulfonylbicyclo[1.1.1]pentanecarboxylic acid; 3-(Methanesulfonyl)-1-bicyclo[1.1.1]pentanecarboxylic acid; [1.1.1]Propellane-3-carboxylic acid, 1-(methylsulfonyl)-; BCP-SO2Me-COOH
EINECS	Contact for details

Quality Control

Our 3-Methanesulfonylbicyclo[1.1.1]pentane-1-carboxylic acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure high purity and consistent identity. Certificates of Analysis (COA) with full specification data are provided for every shipment, supporting compliance in GMP and ISO 9001 environments for research and development use.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at controlled room temperature (15-25°C). The product is moisture-sensitive; keep the container tightly sealed under an inert atmosphere if specified.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥97.0% (Area %)
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.