Description

1,1,1-Trifluoroethyl-Peg5-Tos CAS NO 1872433-61-8 is a specialized PEGylated trifluoroethyl derivative functionalized with a tosylate leaving group, designed as a key intermediate for advanced bioconjugation and pharmaceutical synthesis. This compound is engineered to provide enhanced solubility, stability, and controlled reactivity, which is critical for developing targeted drug delivery systems and high-value fine chemicals. It is primarily required by researchers and manufacturers in the pharmaceutical, biotechnology, and advanced materials sectors for creating novel therapeutics, diagnostic agents, and functional polymers.

Application

• Pharmaceutical Intermediate: A crucial building block for the synthesis of antibody-drug conjugates (ADCs) and other targeted biopharmaceuticals.
• Bioconjugation Linker: Used to attach drugs, dyes, or other functional molecules to proteins, peptides, or nanoparticles via its reactive tosylate group.
• Polymer Modification: Serves as a functional monomer or end-capper for creating fluorinated and PEGylated polymers with unique surface properties.
• Prodrug Synthesis: Employed in the design of prodrugs to improve the pharmacokinetic profile, solubility, and bioavailability of active pharmaceutical ingredients (APIs).
• Diagnostic Agent Development: Utilized in the preparation of contrast agents and molecular imaging probes for medical diagnostics.
• Material Science: Applied in surface engineering to create hydrophilic, low-fouling coatings for medical devices and implants.

Basic Information

Product Name	1,1,1-Trifluoroethyl-Peg5-Tos
CAS No.	1872433-61-8
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	2,5,8,11,14-Pentaoxaheptadecan-17-yl 4-methylbenzenesulfonate, 16,16,16-trifluoro-; 1,1,1-Trifluoro-16-(p-toluenesulfonyloxy)-3,6,9,12,15-pentaoxahexadecane; PEG5-Trifluoroethyl Tosylate; Trifluoroethyl-PEG5-OTs; 2,2,2-Trifluoroethyl tetraethylene glycol tosylate; 16,16,16-Trifluoro-3,6,9,12,15-pentaoxahexadecyl 4-methylbenzenesulfonate; Tos-PEG5-CH2CF3
EINECS	Contact for details

Quality Control

Our 1,1,1-Trifluoroethyl-Peg5-Tos is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure high purity and consistent performance suitable for research and cGMP-grade pharmaceutical applications. Certificates of Analysis (COA) documenting identity, purity, and impurity profiles are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label or CoA. Due to its hygroscopic (moisture-sensitive) nature, the container should be sealed under an inert atmosphere after opening and allowed to equilibrate to room temperature before use to prevent moisture condensation.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or oil
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95% (Area %)
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.