Description

3-Morpholinecarboxamide, Hydrochloride (1:1),(3R)- is a high-purity, single-enantiomer chiral building block and pharmaceutical intermediate. This compound is of significant value in the research and development of novel active pharmaceutical ingredients (APIs), particularly for its role in constructing complex molecular architectures. It is primarily needed by pharmaceutical R&D laboratories, contract research and manufacturing organizations (CROs/CMOs), and fine chemical producers engaged in the synthesis of enantiomerically pure drugs.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the synthesis of potential therapeutic agents, including kinase inhibitors and other small molecule drugs.
• Asymmetric Synthesis: Utilized as a building block in stereoselective chemical reactions to introduce the (R)-configured morpholinecarboxamide moiety.
• Medicinal Chemistry Research: Serves as a crucial scaffold for structure-activity relationship (SAR) studies and lead optimization in drug discovery programs.
• Process Chemistry Development: Used in the scale-up and route scouting for the commercial manufacturing of advanced pharmaceutical intermediates.
• Reference Standard: Can be supplied as a high-purity analytical standard for quality control and method development in analytical laboratories.

Basic Information

Product Name	3-Morpholinecarboxamide, Hydrochloride (1:1),(3R)-
CAS No.	1867908-80-2
Molecular Formula	C5H11ClN2O2
Molecular Weight	166.61 g/mol
Synonyms	(R)-3-Morpholinecarboxamide hydrochloride; (3R)-Morpholine-3-carboxamide hydrochloride; (R)-Morpholine-3-carboxamide HCl; (R)-3-Aminocarbonylmorpholine hydrochloride; (R)-3-Carbamoylmorpholine hydrochloride; (R)-Morpholine-3-carboxylic acid amide hydrochloride; (3R)-3-Morpholinecarboxamide monohydrochloride
EINECS	Contact for details

Quality Control

Our 3-Morpholinecarboxamide, Hydrochloride (1:1),(3R)- is manufactured under a strict quality management system. Each batch is subjected to comprehensive analytical testing, including chiral purity verification, to ensure it meets the high standards required for pharmaceutical R&D. A detailed Certificate of Analysis (COA) providing specifications for identity, purity (HPLC), chiral purity, and related substances is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under dry conditions to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Chiral Purity (Chiral HPLC)	≥99.0% ee
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.