Description

cis-3-Fluoro-Tetrahydro-2H-Pyran-4-Yl Methanesulfonate Racemate is a high-purity chiral building block and pharmaceutical intermediate of significant synthetic utility. Its value lies in the strategic incorporation of both a fluorine atom and a reactive mesylate leaving group on a conformationally constrained tetrahydropyran scaffold, enabling precise structural modifications in advanced molecule synthesis. This compound is essential for research and development chemists in the pharmaceutical and agrochemical industries, particularly for creating novel active ingredients through targeted fluorination and nucleophilic substitution reactions.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the research and development of new active pharmaceutical ingredients (APIs), especially in CNS and metabolic disease therapeutic areas.
• Fluorinated Building Block: Used to introduce fluorine atoms into complex molecules to modulate their lipophilicity, metabolic stability, and bioavailability.
• Agrochemical Synthesis: Serves as a precursor in the development of advanced herbicides, fungicides, and insecticides where the tetrahydropyran moiety is beneficial.
• Material Science Research: Employed in the synthesis of specialized monomers or ligands for advanced polymers and catalytic systems.
• Process Chemistry & Scale-Up: Suitable for use in route scouting and optimization for the commercial-scale production of fluorinated target molecules.
• Medicinal Chemistry: Facilitates structure-activity relationship (SAR) studies by providing a versatile point for further functionalization.

Basic Information

Product Name	cis-3-Fluoro-Tetrahydro-2H-Pyran-4-Yl Methanesulfonate Racemate
CAS No.	1864003-53-1
Molecular Formula	C7H13FO4S
Molecular Weight	212.24 g/mol
Synonyms	4-(Methanesulfonyloxy)-3-fluorooxane (racemic); 3-Fluoro-4-(methylsulfonyloxy)tetrahydro-2H-pyran; cis-3-Fluoro-4-(methylsulfonyloxy)tetrahydropyran; 3-Fluoro-tetrahydropyran-4-yl methanesulfonate; 4-(Methylsulfonyloxy)-3-fluorooxane; (cis)-3-Fluorotetrahydro-2H-pyran-4-yl methanesulfonate; 1864003-53-1; cis-3-Fluoro-THP-4-yl mesylate
EINECS	Contact for details

Quality Control

Our cis-3-Fluoro-Tetrahydro-2H-Pyran-4-Yl Methanesulfonate Racemate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity and chemical identity verification, to ensure it meets the high standards required for pharmaceutical R&D and other critical applications. Certificates of Analysis (COA) with detailed chromatographic data (HPLC/GC) are provided to guarantee consistent quality, lot-to-lot traceability, and compliance with your specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	Racemic mixture (50:50 enantiomer ratio)
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.