Description

(R)-2,2,2-Trifluoro-1-(Tetrahydro-2H-Pyran-4-Yl)Ethanamine Hcl is a high-purity chiral amine building block of significant interest in advanced pharmaceutical synthesis. This compound matters because its trifluoromethyl and tetrahydropyran motifs are key structural features for modulating the potency, metabolic stability, and bioavailability of new drug candidates. It is primarily needed by medicinal chemists and process development scientists in the pharmaceutical and agrochemical industries for the research and development of novel active ingredients.

Application

• Pharmaceutical Intermediate: A critical chiral synthon for the synthesis of novel active pharmaceutical ingredients (APIs), particularly in central nervous system (CNS) and metabolic disease research.
• Agrochemical Research: Used in the development of advanced herbicides, fungicides, and insecticides where the trifluoromethyl group enhances biological activity.
• Ligand & Catalyst Development: Serves as a precursor for chiral ligands and organocatalysts used in asymmetric synthesis.
• Peptidomimetics & PROTACs: Incorporated into complex molecules like peptidomimetics and Proteolysis-Targeting Chimeras (PROTACs) to influence target binding and pharmacokinetic properties.
• Fluorine Chemistry Building Block: Essential for introducing the trifluoromethyl group into complex molecular architectures in medicinal and materials chemistry.
• Process Chemistry & Scale-Up: Supplied for route scouting, optimization, and cGMP manufacturing of clinical trial materials.

Basic Information

Product Name	(R)-2,2,2-Trifluoro-1-(Tetrahydro-2H-Pyran-4-Yl)Ethanamine Hydrochloride
CAS No.	1821820-77-2
Molecular Formula	C7H13ClF3NO
Molecular Weight	219.63 g/mol
Synonyms	(R)-2,2,2-Trifluoro-1-(Tetrahydro-2H-pyran-4-yl)ethanamine hydrochloride; (R)-1-(Tetrahydro-2H-pyran-4-yl)-2,2,2-trifluoroethanamine HCl; (R)-α-(Trifluoromethyl)-4-piperidinemethanol hydrochloride (related); (R)-Tetrahydropyran-4-yl(trifluoromethyl)methylamine hydrochloride; (R)-4-(1-Amino-2,2,2-trifluoroethyl)tetrahydro-2H-pyran hydrochloride; (R)-CF3-THP-methylamine HCl; (R)-Trifluoro-THP-ethylamine hydrochloride
EINECS	Contact for details

Quality Control

Our (R)-2,2,2-Trifluoro-1-(Tetrahydro-2H-Pyran-4-Yl)Ethanamine Hcl is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including chiral HPLC to ensure enantiomeric purity and identity confirmation by NMR and mass spectrometry. Certificates of Analysis (COA) detailing purity, impurities, and physical characteristics are provided with each shipment to ensure compliance with your research and development specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept sealed under an inert atmosphere (e.g., nitrogen or argon) after initial opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.