Description

(2R,4R)-2-Methyltetrahydro-2H-Pyran-4-Ol CAS NO 1821720-33-5 is a high-purity, stereochemically defined chiral building block and intermediate of significant value in advanced organic synthesis. This compound matters for its role in constructing complex molecular architectures with precise three-dimensional control, which is critical for developing active pharmaceutical ingredients (APIs) and functional materials. It is primarily needed by research chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries seeking to introduce specific stereocenters into their target molecules.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the asymmetric synthesis of novel drug candidates, particularly in medicinal chemistry programs targeting central nervous system (CNS) and anti-infective agents.
• Agrochemical Synthesis: Used in the production of enantiomerically pure pesticides and herbicides, where the specific stereochemistry can influence biological activity and environmental profile.
• Ligand and Catalyst Development: Serves as a precursor for chiral ligands and organocatalysts used in asymmetric catalysis, enabling more efficient and selective chemical transformations.
• Flavor and Fragrance Industry: Potential intermediate for the synthesis of stereochemically defined aroma chemicals and natural product analogs.
• Academic and R&D Laboratories: Employed in methodological research for developing new synthetic routes and studying stereoselective reactions.
• Material Science: Can be utilized as a monomer or modifying agent for creating polymers with specific chiral properties for advanced material applications.

Basic Information

Product Name	(2R,4R)-2-Methyltetrahydro-2H-Pyran-4-Ol
CAS No.	1821720-33-5
Molecular Formula	C6H12O2
Molecular Weight	116.16 g/mol
Synonyms	(2R,4R)-2-Methyl-4-hydroxytetrahydro-2H-pyran; (2R,4R)-2-Methyltetrahydropyran-4-ol; (2R,4R)-2-Methyl-4-tetrahydropyranol; (2R,4R)-4-Hydroxy-2-methyltetrahydropyran; cis-2-Methyltetrahydropyran-4-ol (stereospecific); Chiral THP alcohol derivative; (2R,4R)-MTHP-ol; 1821720-33-5
EINECS	Contact for details

Quality Control

Our (2R,4R)-2-Methyltetrahydro-2H-Pyran-4-Ol is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure high chiral purity and chemical integrity, meeting the exacting standards required for advanced synthetic applications. Certificates of Analysis (COA) detailing chiral HPLC assay, enantiomeric excess (ee), and impurity profiles are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). The product may be hygroscopic (moisture-sensitive); keep the container tightly sealed under an inert atmosphere if specified.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC/HPLC)	≥ 97.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Specific Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.